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Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation
Communications Biology ( IF 5.9 ) Pub Date : 2021-02-22 , DOI: 10.1038/s42003-021-01741-x
Travis T Sims 1 , Molly B El Alam 2 , Tatiana V Karpinets 3 , Stephanie Dorta-Estremera 4 , Venkatesh L Hegde 4 , Sita Nookala 4 , Kyoko Yoshida-Court 2 , Xiaogang Wu 3 , Greyson W G Biegert 2 , Andrea Y Delgado Medrano 2 , Travis Solley 2 , Mustapha Ahmed-Kaddar 2 , Bhavana V Chapman 2 , K Jagannadha Sastry 4 , Melissa P Mezzari 5 , Joseph F Petrosino 5 , Lilie L Lin 2 , Lois Ramondetta 1 , Anuja Jhingran 2 , Kathleen M Schmeler 1 , Nadim J Ajami 3 , Jennifer Wargo 6 , Lauren E Colbert 2 , Ann H Klopp 2
Affiliation  

Diversity of the gut microbiome is associated with higher response rates for cancer patients receiving immunotherapy but has not been investigated in patients receiving radiation therapy. Additionally, current studies investigating the gut microbiome and outcomes in cancer patients may not have adjusted for established risk factors. Here, we sought to determine if diversity and composition of the gut microbiome was independently associated with survival in cervical cancer patients receiving chemoradiation. Our study demonstrates that the diversity of gut microbiota is associated with a favorable response to chemoradiation. Additionally, compositional variation among patients correlated with short term and long-term survival. Short term survivor fecal samples were significantly enriched in Porphyromonas, Porphyromonadaceae, and Dialister, whereas long term survivor samples were significantly enriched in Escherichia Shigella, Enterobacteriaceae, and Enterobacteriales. Moreover, analysis of immune cells from cervical tumor brush samples by flow cytometry revealed that patients with a high microbiome diversity had increased tumor infiltration of CD4+ lymphocytes as well as activated subsets of CD4 cells expressing ki67+ and CD69+ over the course of radiation therapy. Modulation of the gut microbiota before chemoradiation might provide an alternative way to enhance treatment efficacy and improve treatment outcomes in cervical cancer patients.



中文翻译:

肠道微生物组多样性是接受放化疗的宫颈癌患者生存的独立预测因子

肠道微生物组的多样性与接受免疫治疗的癌症患者的较高反应率有关,但尚未在接受放射治疗的患者中进行过研究。此外,目前调查癌症患者肠道微生物组和结果的研究可能没有针对已确定的风险因素进行调整。在这里,我们试图确定肠道微生物组的多样性和组成是否与接受放化疗的宫颈癌患者的生存独立相关。我们的研究表明,肠道微生物群的多样性与对化放疗的良好反应有关。此外,患者的成分差异与短期和长期生存相关。短期幸存者粪便样本显着富含卟啉单胞菌PorphyromonadaceaeDialister,而长期存活的样本显着富集了Escherichia Shigella 、 EnterobacteriaceaeEnterobacteriales。此外,通过流式细胞术对宫颈肿瘤刷样中的免疫细胞进行的分析表明,微生物组多样性高的患者在放疗过程中 CD4+ 淋巴细胞的肿瘤浸润增加,表达 ki67+ 和 CD69+ 的 CD4 细胞的活化亚群增加。在放化疗前调节肠道微生物群可能提供一种替代方法来提高宫颈癌患者的治疗效果和改善治疗结果。

更新日期:2021-02-22
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