Abstract

Objective

To study the efficacy of LITT for BM patients experiencing in-field recurrence following SRS.

Methods

A literature search was conducted to identify studies investigating local control (LC) rate and overall survival (OS) of LITT for BMs with IFR following SRS.

Results

Analysis included 14 studies (470 patients with 542 lesions). The 6-month (LC-6) and 12-month (LC-12) local control rates were 78.5% (95% CI: 70.6–84.8%) and 69.0% (95% CI: 60.0–76.7%) separately. Pooled median OS was 17.15 months (95% CI: 13.27–24.8). The overall OS-6 and OS-12 rates were 76.0% (95% CI: 71.4–80.0%) and 63.4% (95% CI: 52.9–72.7%) separately. LITT provided more favorable local control efficacy in RN than BM recurrence (LC-6: 87.4% vs. 67.9%, p = 0.009; LC-12: 76.3% vs. 59.9%, p = 0.041).

Conclusions

LITT is an effective treatment for BM patients experiencing IFR following SRS. For different pathological entities, LITT showed more satisfactory local control efficacy on RN than BM recurrence.

中文翻译：

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激光间质热疗对 SRS 后现场复发脑转移瘤的疗效：系统评价和荟萃分析

摘要

客观的

研究 LITT 对 SRS 后现场复发的 BM 患者的疗效。

方法

进行了文献检索，以确定研究 LITT 对 SRS 后 IFR BMs 的局部控制 (LC) 率和总生存期 (OS) 的研究。

结果

分析包括 14 项研究（470 名患者，542 个病灶）。6个月（LC-6）和12个月（LC-12）局部控制率分别为78.5%（95% CI：70.6-84.8%）和69.0%（95% CI：60.0-76.7%）。合并的中位 OS 为 17.15 个月（95% CI：13.27–24.8）。总体 OS-6 和 OS-12 率分别为 76.0% (95% CI: 71.4–80.0%) 和 63.4% (95% CI: 52.9–72.7%)。LITT 在 RN 中提供了比 BM 复发更有利的局部控制效果（LC-6：87.4% 对 67.9%，p  = 0.009；LC-12：76.3% 对 59.9%，p  = 0.041）。

结论

LITT 是治疗 SRS 后出现 IFR 的 BM 患者的有效治疗方法。对于不同的病理实体，LITT 对 RN 的局部控制效果比 BM 复发更令人满意。