Abstract

Objective

To explore the feasibility of high-intensity focused ultrasound (HIFU) ablation for treating metastatic pelvic tumors and recurrent ovary cancer.

Materials and methods

Eight patients with metastatic pelvic tumors or recurrent ovary cancer were enrolled in this study. Among them, 5 patients had ovarian cancer, 1 had cervical cancer, 1 had endometrial cancer, and 1 had rectal cancer. Six of them received abdominal surgical operation for their primary cancer, no one received radiotherapy. HIFU treatment was performed under conscious sedation. Vital signs were monitored during the procedure, and adverse effects were recorded. Postoperative follow-up was performed to observe pain relief and the improvement of the patient’s quality of life.

Results

The median age of the patients was 54 (range: 33–76) years, with a total of 12 lesions. The average volume of the lesions was 238.0 cm³. Six patients completed 12 months follow-up. Postoperative pain relief rate was 60% (3/5), and the quality of life improved in the short term. The main adverse effect of HIFU was pain in the treated area, with the pain score lower than 4, and all of which was self-relieved within 1 day after HIFU treatment. No serious complications such as skin burn, intestinal perforation, and nerve injury occurred.

Conclusion

HIFU is feasible for the treatment of metastatic pelvic tumors or recurrent ovary cancer without serious complications. Therefore, HIFU seems a promising treatment for recurrent ovary cancer, metastatic pelvic tumors from cervical cancer, endometrial cancer, and rectal cancer.

中文翻译：

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高强度聚焦超声消融治疗复发性卵巢癌和转移性盆腔肿瘤的可行性研究

摘要

目标

探讨高强度聚焦超声（HIFU）消融治疗转移性盆腔肿瘤和复发性卵巢癌的可行性。

材料和方法

八名患有转移性盆腔肿瘤或复发性卵巢癌的患者参加了这项研究。其中卵巢癌5例，宫颈癌1例，子宫内膜癌1例，直肠癌1例。其中6人因原发癌接受腹部外科手术，无一人接受放疗。HIFU 治疗在清醒镇静下进行。在手术过程中监测生命体征，并记录不良反应。术后随访观察疼痛缓解情况及患者生活质量改善情况。

结果

患者的中位年龄为 54（范围：33-76）岁，共有 12 个病灶。病变的平均体积为238.0 cm ³。6 名患者完成了 12 个月的随访。术后疼痛缓解率为60%（3/5），短期内生活质量有所改善。HIFU的主要不良反应为治疗部位疼痛，疼痛评分低于4分，且均在HIFU治疗后1天内自行缓解。未发生皮肤烧伤、肠穿孔、神经损伤等严重并发症。

结论

HIFU 可用于治疗转移性盆腔肿瘤或复发性卵巢癌，且无严重并发症。因此，HIFU 似乎是治疗复发性卵巢癌、宫颈癌转移性盆腔肿瘤、子宫内膜癌和直肠癌的一种有前途的治疗方法。