ABSTRACT

Introduction

Proteins are molecules that have role in the progression of the diseases. Proteomics is a tool that can play an effective role in identifying diagnostic and therapeutic biomarkers for lung cancer. Cytokines are proteins that play a decisive role in activating body's immune system in lung cancer. They can increase the growth of the tumor (oncogenic cytokines) or limit tumor growth (anti-tumor cytokines) by regulating related signaling pathways such as proliferation, growth, metastasis, and apoptosis.

Areas covered

In the present study, a total of 223 papers including 196 research papers and 27 review papers, extracted from PubMed and Scopus and published from 1997 to present, are reviewed. The most important involved-cytokines in lung cancer including TNF-α, IFN- γ, TGF-β, VEGF and interleukins such as IL-6, IL-17, IL-8, IL-10, IL-22, IL-1β and IL-18 are introduced. Also, the pathological and biological role of such cytokines in cancer signaling pathways is explained.

Expert opinion

In lung cancer, the cytokine expression changes under the physiological conditions of the immune system, and inflammatory cytokines are associated with the progression of lung cancer. Therefore, the cytokine expression profile can be used in the diagnosis, prognosis, prediction of therapeutic responses, and survival of patients with lung cancer.

中文翻译：

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肺癌细胞因子蛋白质组学研究：综述

摘要

介绍

蛋白质是在疾病进展中起作用的分子。蛋白质组学是一种可以在识别肺癌诊断和治疗生物标志物方面发挥有效作用的工具。细胞因子是在肺癌中对激活人体免疫系统起决定性作用的蛋白质。它们可以通过调节增殖、生长、转移和凋亡等相关信号通路来促进肿瘤的生长（致癌细胞因子）或限制肿瘤的生长（抗肿瘤细胞因子）。

覆盖区域

本研究共回顾了 223 篇论文，其中包括 196 篇研究论文和 27 篇评论论文，这些论文摘自 PubMed 和 Scopus，并从 1997 年至今发表。肺癌中最重要的细胞因子包括 TNF-α、IFN-γ、TGF-β、VEGF 和白介素，如 IL-6、IL-17、IL-8、IL-10、IL-22、IL-1β和 IL-18 被引入。此外，还解释了此类细胞因子在癌症信号通路中的病理和生物学作用。

专家意见

在肺癌中，细胞因子表达在免疫系统生理条件下发生变化，炎症细胞因子与肺癌的进展有关。因此，细胞因子表达谱可用于肺癌患者的诊断、预后、治疗反应的预测和存活。