Nano Express Pub Date : 2021-02-19 , DOI: 10.1088/2632-959x/abe343 Valentina Olifirenko 1 , Aiganym Abduraimova 1 , Moon Sung Kang 2 , Iruthayapandi Selestin Raja 2 , Bakyt Duisenbayeva 3 , Anara Molkenova 4 , Laura Khamkhash 5 , Yoon-Hwae Hwang 6 , Dong-Wook Han 2 , Timur Sh Atabaev 4
Rare-earth metal oxide nanoparticles considered promising contrast agents for x-ray computed tomography (CT) and magnetic resonance imaging (MRI). The main purpose of this study is to investigate the potential applicability of polyethyleneimine (PEI)-coated Eu2O3 and Dy2O3 nanoparticles (NPs) for CT x-ray attenuation. Morphology and other physicochemical properties of prepared samples were systematically investigated using a range of characterization tools. Preliminary cytotoxicity experiments with L-929 fibroblastic cells suggested that both samples have no significant toxicity at concentrations below 100 μg ml−1. Clinical CT analysis shows that PEI@Eu2O3 NPs exhibit higher x-ray attenuation efficiency (∼8 HU mM−1) as compared to PEI@Dy2O3 NPs (∼5 HU mM−1).
中文翻译:
聚乙烯亚胺 PEI 包覆的 Eu 2 O 3和 Dy 2 O 3纳米粒子在计算机断层扫描中增强对比度的潜在适用性
稀土金属氧化物纳米粒子被认为是用于 X 射线计算机断层扫描 (CT) 和磁共振成像 (MRI) 的有前途的造影剂。本研究的主要目的是研究聚乙烯亚胺 (PEI) 涂层的 Eu 2 O 3和 Dy 2 O 3纳米粒子 (NPs) 对 CT x 射线衰减的潜在适用性。使用一系列表征工具系统地研究了制备样品的形态学和其他物理化学性质。L-929 成纤维细胞的初步细胞毒性实验表明,两种样品在低于 100 μ g ml -1 的浓度下都没有显着的毒性。临床 CT 分析表明 PEI@Eu 2 O3个纳米粒子显示出更高的x射线衰减效率(〜8 HU毫-1相比PEI @的Dy)2 ö 3个纳米颗粒(〜5 HU毫-1)。