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Advancing and refining archaeological dental calculus research using multiomic frameworks
STAR: Science & Technology of Archaeological Research Pub Date : 2021-02-19 , DOI: 10.1080/20548923.2021.1882122
Sterling L. Wright 1 , Keith Dobney 2 , Laura S. Weyrich 1, 3
Affiliation  

ABSTRACT

Dental calculus (calcified dental plaque) is a cross-cultural biological matrix that is emerging as a critical source of information for anthropologists and oral health professionals. It contains a multitude of diverse biomolecules, providing information about an individual’s culture, diet, ancestry, and health. Most researchers who study archaeological dental calculus use genomic or proteomic approaches, although a wide range of other techniques are now available. However, few studies have utilized efficient multiomic protocols. This lack of integration is problematic, as such approaches in other fields have proven to improve results and strengthen interpretations. Our review discusses three multiomic approaches: (1) interactions between the metaproteome and metagenome; (2) relationships between the host genome and oral metagenome; and, (3) associations between the epigenome and metagenome. We draw from multiomic studies on soil, plant, gut, and modern oral microbiomes to demonstrate how such integration can provide insights that are not attainable with single-omic approaches.



中文翻译:

使用多组学框架推进和完善考古学牙结石的研究

摘要

牙结石(钙化牙菌斑)是一种跨文化的生物基质,正在成为人类学家和口腔保健专业人员的重要信息来源。它包含多种多样的生物分子,可提供有关个人的文化,饮食,血统和健康的信息。大多数研究考古学牙结石的研究人员都使用基因组或蛋白质组学方法,尽管现在可以使用多种其他技术。但是,很少有研究利用有效的多组学协议。缺乏集成是有问题的,因为其他领域的这种方法已被证明可以改善结果并加强解释。我们的综述讨论了三种多组学方法:(1)元蛋白质组和元基因组之间的相互作用;(2)宿主基因组与口腔基因组的关系;和,(3)表观基因组与元基因组之间的关联。我们从对土壤,植物,肠道和现代口腔微生物组学的多组学研究中汲取了经验,以证明这种整合如何能够提供单组学方法无法获得的见解。

更新日期:2021-02-21
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