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The Relationship between Oxidative Stress and Anxiety in a Healthy Older Population
Experimental Aging Research ( IF 1.8 ) Pub Date : 2021-02-20 , DOI: 10.1080/0361073x.2021.1883966
Karen Savage 1, 2 , Davy Kingshott 1 , Andrew Gubko 1 , Alicia Wt Thee 1 , Tamer Burjawi 1 , Kevin Croft 3 , Jerome Sarris 2, 4 , Con Stough 1
Affiliation  

ABSTRACT

Background/study context: F2-Isoprostanes are putative markers of oxidative stress, one of the processes associated with biological senescence. Evidence exists for elevated F2-Isoprostanes in chronic conditions including psychiatric disorders. Few studies have examined the relationship between oxidative stress and mood in older healthy samples, to establish the influence on mental health. Given current aging demographics in many nations, management of brain and mental health is crucial for longevity, chronic disease management, and quality of life.

Method: We investigated the relationship between F2-Isoprostanes, a marker for oxidative stress, and anxiety and mood in 262 healthy adults aged 60–75 years, using baseline data from the Australian Research Council Longevity Intervention (ARCLI; ANZCTR12611000487910), a 12-month nutraceutical intervention study.

Results: Higher F2 levels significantly predicted increased Depression-dejection and Anger-hostility subscale scores from the Profile of Mood States (POMS). Fatigue-inertia subscale was predicted by increased Body Mass Index. Spielberger State-Trait Inventory (STAI) scores were significantly higher in females.

Conclusion: While the primary outcome data did not find a definitive relationship between F2 and total mood or general anxiety levels, the sub-scale data adds weight toward growing literature that biological processes such as oxidative stress are in part related to mood. This is a modifiable risk factor contributing to physical and mental wellbeing that are crucial to healthy aging.



中文翻译:

健康老年人群中氧化应激与焦虑之间的关系

摘要

背景/研究背景 F 2 -异前列烷是氧化应激的推定标志物,氧化应激是与生物衰老相关的过程之一。有证据表明,包括精神疾病在内的慢性病中F 2 -异前列烷升高。很少有研究检查老年健康样本中氧化应激与情绪之间的关系,以确定对心理健康的影响。鉴于当前许多国家人口老龄化,大脑和心理健康管理对于长寿、慢性病管理和生活质量至关重要。

方法我们使用澳大利亚研究委员会长寿干预 (ARCLI; ANZCTR12611000487910) 的基线数据,调查了 262 名 60-75 岁健康成年人的氧化应激标志物F 2 -异前列烷与焦虑和情绪之间的关系,12个月的营养干预研究。

结果较高的 F2 水平显着预测了来自情绪状态概况 (POMS) 的抑郁-沮丧和愤怒-敌意分量表得分的增加。疲劳惯性子量表是通过增加的体重指数来预测的。Spielberger State-Trait Inventory (STAI) 得分在女性中明显更高。

结论虽然主要结果数据没有发现 F2 与总情绪或一般焦虑水平之间的明确关系,但子量表数据增加了越来越多的文献的权重,即氧化应激等生物过程部分与情绪有关。这是一个可改变的风险因素,有助于身心健康,这对健康老龄化至关重要。

更新日期:2021-02-20
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