Apelin is an endogenous ligand of G protein-coupled receptor APJ. In recent years, many studies have shown that the apelin/APJ system has neuroprotective properties, such as anti-inflammatory, anti-oxidative stress, anti-apoptosis, and regulating autophagy, blocking excitatory toxicity. Apelin/APJ system has been proven to play a role in various neurological diseases and may be a promising therapeutic target for nervous system diseases. In this paper, the neuroprotective properties of the apelin/APJ system and its role in neurologic disorders are reviewed. Further understanding of the pathophysiological effect and mechanism of the apelin/APJ system in the nervous system will help develop new therapeutic interventions for various neurological diseases.

Apelin 是 G 蛋白偶联受体 APJ 的内源性配体。近年来，许多研究表明apelin/APJ系统具有神经保护特性，如抗炎、抗氧化应激、抗细胞凋亡、调节自噬、阻断兴奋性毒性等。Apelin/APJ 系统已被证明在各种神经系统疾病中发挥作用，可能是神经系统疾病的一个有前景的治疗靶点。本文综述了 apelin/APJ 系统的神经保护特性及其在神经系统疾病中的作用。进一步了解apelin/APJ系统在神经系统中的病理生理作用和机制，将有助于开发针对各种神经系统疾病的新的治疗干预措施。