L-kynurenine (L-kyn) is a marker of prostate cancer. At present, the expensive instruments are usually applied to detect L-kyn clinically, which limits its wide application for cancer diagnosis. Herein, three lanthanide metal–organic frameworks ([Ln(CHO₂)₃]_n, Ln = Eu, Gd, and Tb) were designed and obtained, and detailly characterized by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and luminescence spectroscopy. Further study reveals that [Tb(CHO₂)₃]_n is a highly selective, ultra-sensitive, of strong anti-interference, highly stable, and non-expensive sensor for prostate cancer marker L-kyn. The limit of detection (LOD) for L-kyn sensing is a highly sensitive value of 1.0 × 10⁻⁹ mol/L. Furthermore, the sensing mechanism is discussed in detail.

L-犬尿氨酸 (L-kyn) 是前列腺癌的标志物。目前临床上检测L-kyn的仪器价格昂贵，限制了其在癌症诊断中的广泛应用。在此，设计并获得了三种镧系金属有机骨架（[Ln(CHO ₂ ) ₃ ] _n，Ln = Eu，Gd和Tb），并通过单晶X射线衍射（SCXRD）、粉末X-射线衍射（PXRD）、傅里叶变换红外光谱（FT-IR）、热重分析（TGA）和发光光谱。进一步研究表明 [Tb(CHO ₂ ) ₃ ] _n是一种高选择性、超灵敏、强抗干扰、高稳定性、低成本的前列腺癌标志物L-kyn传感器。L-kyn 传感的检测限 (LOD) 是 1.0 × 10 ^-9  mol/L 的高灵敏度值。此外，还详细讨论了传感机制。