This study constructed a new non-linear model of myocardial electrical conduction block during photosensitization reaction to identify the vulnerable cell population and generate an index for recurrent risk following catheter ablation for tachyarrhythmia. A three-compartment model of conductive, vulnerable, and blocked cells was proposed. To determine the non-linearity of the rate parameter for the change from vulnerable cells to conductive cells, we compared a previously reported non-linear model and our newly proposed model with non-linear rate parameters in the modeling of myocardial cell electrical conduction block during photosensitization reaction. The rate parameters were optimized via a bi-nested structure using measured synchronicity data during the photosensitization reaction of myocardial cell wires. The newly proposed model had a better fit to the measured data than the conventional model. The sum of the error until the time where the measured value was higher than 0.6, was 0.22 in the conventional model and 0.07 in our new model. The non-linear rate parameter from the vulnerable cell to the conductive cell compartment may be the preferred structure of the electrical conduction block model induced by photosensitization reaction. This simulation model provides an index to evaluate recurrent risk after tachyarrhythmia catheter ablation by photosensitization reaction.

Graphical abstract

中文翻译：

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光敏过程中心肌细胞传导阻滞的三室非线性模型

本研究构建了一个新的光敏反应期间心肌电传导阻滞的非线性模型，以识别易受攻击的细胞群，并生成导管消融治疗快速性心律失常后复发风险的指数。提出了导电、脆弱和阻塞细胞的三室模型。为了确定从易损细胞到导电细胞变化的速率参数的非线性，我们比较了先前报道的非线性模型和我们新提出的具有非线性速率参数的模型，在心肌细胞电传导阻滞的建模过程中光敏反应。在心肌细胞丝的光敏反应期间，使用测量的同步数据通过双嵌套结构优化速率参数。新提出的模型比传统模型更适合测量数据。直到测量值高于 0.6 时的误差总和，在传统模型中为 0.22，在我们的新模型中为 0.07。从易损细胞到导电细胞室的非线性速率参数可能是光敏反应诱导的导电块模型的优选结构。该模拟模型为评估光敏反应引起的快速心律失常导管消融术后复发风险提供了一个指标。从易损细胞到导电细胞室的非线性速率参数可能是光敏反应诱导的导电块模型的优选结构。该模拟模型为评估光敏反应引起的快速心律失常导管消融术后复发风险提供了一个指标。从易损细胞到导电细胞室的非线性速率参数可能是光敏反应诱导的导电块模型的优选结构。该模拟模型为评估光敏反应引起的快速心律失常导管消融术后复发风险提供了一个指标。

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