Co-substituted hydroxyapatite (HAP) with cationic rubidium (Rb⁺) and anionic selenite (\({\text{SeO}}_{3}^{2 - }\)) was synthesized at different contributions of Rb⁺ ions. The chemical formula of the composition is [Rb_xCa_(10–0.5x)(PO₄)₅(SeO₃)(OH)₂], where 0 ≤ x ≤ 0.8 with step 0.2. The structure and morphology of the as-prepared compositions were investigated upon the concentration of (Rb⁺) ions. It was mentioned that the roughness average (R_a) starts from 26.2 nm and grows up, reaching 42.6 nm. This noticeable roughness degree due to Rb insertions is reflected in adhesive ability in the biological environment. Rubidium dopant has a significant effect on particle size that inhibits size growth. The internal porosity could be classified as micropores except at x = 0.6 and 0.8, which are considered macro-pores. Rb/Se-HAP compositions' cell viability was investigated through the human osteoblast cell line (HFB4), and the life ratio achieved around 98.1 ± 3.9%. Furthermore, the additional Rb⁺ ions promote antibacterial activity, whereas the inhibition zone started from 1.6 ± 0.2 and 1.3 ± 0.3 mm and grew up to 5.3 ± 0.9 and 4.9 ± 0.8 mm for x = 0.0 and 0.8, against E. coli and S. aureus, respectively. Thus, the reported stoichiometric compositions are considered to be promising materials for biomedical applications.

在Rb ⁺离子的不同贡献下，合成了具有阳离子rub（Rb ⁺）和阴离子亚硒酸盐（\（{\ text {SeO}} _ {3} ^ {2--} \）的共取代羟基磷灰石（HAP）。该组合物的化学式为[RB _X的Ca _{（10-0.5x）}（PO ₄）₅（SEO ₃）（OH）₂ ]，其中0≤  X  ≤0.8与步骤0.2。根据（Rb ⁺）离子的浓度研究了所制备的组合物的结构和形态。提到了粗糙度平均值（R _a）从26.2 nm开始并长大，达到42.6 nm。由于Rb插入而引起的这种明显的粗糙度反映在生物环境中的粘附能力上。id掺杂剂对粒径有显着影响，从而抑制了粒径的增长。内部孔隙率可以分类为微孔，但x  = 0.6和0.8除外，它们被认为是大孔。通过人类成骨细胞系（HFB4）研究了Rb / Se-HAP组合物的细胞生存力，其寿命比达到98.1±3.9％。此外，额外的Rb ⁺离子可增强抗菌活性，而抑制区从1.6±0.2和1.3±0.3 mm开始，并在针对x  = 0.0和0.8的情况下增长到5.3±0.9和4.9±0.8 mm （针对大肠杆菌）和金黄色葡萄球菌。因此，所报道的化学计量组成被认为是用于生物医学应用的有前途的材料。