Cancers are selectively sensitive to methionine (MET) restriction (MR) due to their addiction to MET which is overused for elevated methylation reactions. MET addiction of cancer was discovered by us 45 years ago. MR of cancer results in depletion of S-adenosylmethionine (SAM) for transmethylation reactions, resulting in selective cancer-growth arrest in the late S/G₂-phase of the cell cycle. The aim of the present study was to determine if blockade of the MET-methylation axis is a highly-effective strategy for cancer chemotherapy.

中文翻译：

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组合甲硫氨酸-甲基化轴阻断：一种靶向癌症甲硫氨酸成瘾的新方法。

癌症对甲硫氨酸 (MET) 限制 (MR) 有选择性敏感，因为它们对 MET 上瘾，MET 过度用于升高的甲基化反应。癌症的 MET 成瘾是我们 45 年前发现的。癌症的 MR 导致用于转甲基化反应的 S-腺苷甲硫氨酸 (SAM) 耗尽，导致细胞周期晚期 S/G ₂期的选择性癌症生长停滞。本研究的目的是确定阻断 MET 甲基化轴是否是癌症化疗的高效策略。