A magnetic drug-targeting system featuring real-time imaging, guidance, and local heating is required for more precise drug targeting and minimization of side effects. In this article, we present a novel electromagnetic navigation and heating system that not only guides and navigates magnetic nanoparticles (MNPs) with real-time imaging feedback, but also uses focused MNP heating to release drugs while monitoring the temperature. The magnetic field amplitude and magnetic gradient play key roles in our integrated system; we enhanced the gradient and field within a field of view of 30 × 30 mm. Performance was examined via simulation employing COMSOL Multiphysics software and verified experimentally. After optimization, the maximum gradients attained on the x and y axes are 4.15 and 2.23 T/m/μ ₀ , respectively, for the electromagnetic actuator mode, and 8.48 T/m/μ ₀ for the magnetic particle imaging mode. The magnetic field amplitude for heating was 19.70 mT at 100 kHz. We then built a two-dimensional MNPs navigation/heating system to demonstrate the in vitro feasibility of our scheme; this afforded a 1-Hz navigation update rate during MNPs guidance in a Y-shaped channel and locally heated MNPs with temperature monitoring.

中文翻译：

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新型二维电磁导航系统的优化设计和实现，该系统可以集中加热磁性纳米粒子

需要具有实时成像，引导和局部加热功能的磁性药物靶向系统，以实现更精确的药物靶向和最小化副作用。在本文中，我们提出了一种新颖的电磁导航和加热系统，该系统不仅可以引导和导航具有实时成像反馈的磁性纳米粒子（MNP），而且可以使用聚焦的MNP加热来释放药物，同时监控温度。磁场振幅和磁场梯度在我们的集成系统中起着关键作用；我们在30×30 mm的视场内增强了梯度和视场。通过使用COMSOL Multiphysics软件进行的仿真检查了性能，并进行了实验验证。经过优化后，在X 和 ÿ轴是4.15和2.23 T / M /μ ₀ ，分别用于电磁致动器模式，和8.48 T / M /μ ₀为磁性粒子成像模式。加热的磁场振幅在100 kHz时为19.70 mT。然后，我们构建了二维MNP导航/加热系统，以演示体外我们计划的可行性；这样，在Y形通道中的MNP引导期间以及在进行温度监控的情况下，局部加热的MNP可以提供1-Hz的导航更新率。