The recruitment of neutrophil to the primary cancer has been shown to be steered by neoplastic cells or tumor-educated mesenchymal stromal cells and has a prometastatic effect. However, the neutrophil chemotaxis and their interaction with tumor cells in the distal metastasized tissues remain elusive. In this review, we discussed emerging research on the interaction between neutrophil recruitment and tumor metastasis, which is essential for studying tumor cell invasion and related immunotherapy.

中文翻译：

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肿瘤微环境中中性粒细胞募集的异质性和转移前生态位的形成

中性粒细胞向原发性癌症的募集已被证明是由肿瘤细胞或肿瘤培养的间充质基质细胞引导的，并且具有促转移作用。然而，中性粒细胞的趋化性及其与远端转移组织中肿瘤细胞的相互作用仍然难以捉摸。在这篇综述中，我们讨论了有关中性粒细胞募集和肿瘤转移之间相互作用的新兴研究，这对于研究肿瘤细胞侵袭和相关免疫治疗至关重要。