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Time resolved speckle contrast optical spectroscopy at quasi-null source-detector separation for non-invasive measurement of microvascular blood flow
Biomedical Optics Express ( IF 3.4 ) Pub Date : 2021-02-19 Marco Pagliazzi, Lorenzo Colombo, Ernesto E. Vidal-Rosas, Tanja Dragojević, Veronika Parfentyeva, Joseph P. Culver, Sanathana Konugolu Venkata Sekar, Laura Di Sieno, Davide Contini, Alessandro Torricelli, Antonio Pifferi, Alberto Dalla Mora, and Turgut Durduran
Biomedical Optics Express ( IF 3.4 ) Pub Date : 2021-02-19 Marco Pagliazzi, Lorenzo Colombo, Ernesto E. Vidal-Rosas, Tanja Dragojević, Veronika Parfentyeva, Joseph P. Culver, Sanathana Konugolu Venkata Sekar, Laura Di Sieno, Davide Contini, Alessandro Torricelli, Antonio Pifferi, Alberto Dalla Mora, and Turgut Durduran
Time (or path length) resolved speckle contrast optical spectroscopy (TD-SCOS) at quasi-null (2.85 mm) source-detector separation was developed and demonstrated. The method was illustrated by in vivo studies on the forearm muscle of an adult subject. The results have shown that selecting longer photon path lengths results in higher hyperemic blood flow change and a faster return to baseline by a factor of two after arterial cuff occlusion when compared to SCOS without time resolution. This indicates higher sensitivity to the deeper muscle tissue. In the long run, this approach may allow the use of simpler and cheaper detector arrays compared to time resolved diffuse correlation spectroscopy that are based on readily available technologies. Hence, TD-SCOS may increase the performance and decrease cost of devices for continuous non-invasive, deep tissue blood flow monitoring.
中文翻译:
准无效源-检测器分离中的时间分辨散斑对比光谱法,用于微血管血流的非侵入性测量
准零(2.85 mm)源-检测器分离的时间(或路径长度)分辨散斑对比光谱法(TD-SCOS)得到了开发和证明。该方法通过体内说明研究成人受试者的前臂肌肉。结果表明,与没有时间分辨力的SCOS相比,选择更长的光子路径长度会导致更高的充血血流量变化,并且在动脉套扎后较快返回基线,速度是原来的两倍。这表明对较深的肌肉组织有更高的敏感性。从长远来看,与基于容易获得的技术的时间分辨扩散相关光谱相比,这种方法可以允许使用更简单,更便宜的检测器阵列。因此,TD-SCOS可以提高用于连续无创,深层组织血流监测的设备的性能并降低其成本。
更新日期:2021-02-19
中文翻译:
准无效源-检测器分离中的时间分辨散斑对比光谱法,用于微血管血流的非侵入性测量
准零(2.85 mm)源-检测器分离的时间(或路径长度)分辨散斑对比光谱法(TD-SCOS)得到了开发和证明。该方法通过体内说明研究成人受试者的前臂肌肉。结果表明,与没有时间分辨力的SCOS相比,选择更长的光子路径长度会导致更高的充血血流量变化,并且在动脉套扎后较快返回基线,速度是原来的两倍。这表明对较深的肌肉组织有更高的敏感性。从长远来看,与基于容易获得的技术的时间分辨扩散相关光谱相比,这种方法可以允许使用更简单,更便宜的检测器阵列。因此,TD-SCOS可以提高用于连续无创,深层组织血流监测的设备的性能并降低其成本。