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Sex differences in adult social, cognitive, and affective behavioral deficits following neonatal phlebotomy‐induced anemia in mice
Brain and Behavior ( IF 3.1 ) Pub Date : 2021-02-19 , DOI: 10.1002/brb3.1780
Tatyana M Matveeva 1 , Garima Singh 2 , Tate A Gisslen 2 , Jonathan C Gewirtz 1, 3 , Michael K Georgieff 2
Affiliation  

Anemia is common in prematurely born infants due to blood loss resulting from frequent phlebotomies and may contribute to their neurobehavioral deficits. Preclinical models of phlebotomy‐induced anemia (PIA) have revealed metabolic and genomic changes in multiple brain structures of young mice, yet the impact of neonatal PIA on early‐life and adult behavior has not been assessed.

中文翻译:

新生儿静脉放血引起的贫血后成年社交,认知和情感行为缺陷的性别差异

由于频繁的静脉切开术导致失血,贫血在早产儿中很常见,并且可能导致他们的神经行为缺陷。放血性贫血(PIA)的临床前模型已揭示了幼鼠多脑结构的代谢和基因组变化,但尚未评估新生儿PIA对早期生命和成年行为的影响。
更新日期:2021-03-26
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