Curcuma longa (C. longa) or turmeric is a plant with a long history of use in traditional medicine, especially for treating inflammatory conditions C. longa and its main constituent, curcumin (CUR), showed various pharmacological effects such as antioxidant and anti-microbial properties. The updated knowledge of anti-inflammatory, antioxidant, and immunomodulatory effects of C. longa and CUR is provided in this review article. Pharmacological effects of C. longa, and CUR, including anti-inflammatory, antioxidant, and immunomodulatory properties, were searched using various databases and appropriate keywords until September 2020. Various studies showed anti-inflammatory effects of C. longa and CUR, including decreased white blood cell, neutrophil, and eosinophil numbers, and its protective effects on serum levels of inflammatory mediators such as phospholipase A2 and total protein in different inflammatory disorders. The antioxidant effects of C. longa and CUR were also reported in several studies. The plant extracts and CUR decreased malondialdehyde and nitric oxide levels but increased thiol, superoxide dismutase, and catalase levels in oxidative stress conditions. Treatment with C. longa and CUR also improved immunoglobulin E (Ig)E, pro-inflammatory cytokine interleukin 4 (IL)-4, transforming growth factor-beta, IL-17, interferon-gamma levels, and type 1/type 2 helper cells (Th1)/(Th2) ratio in conditions with disturbance in the immune system. Therefore C. longa and CUR showed anti-inflammatory, antioxidant, and immunomodulatory effects, indicating a potential therapeutic effect of the plant and its constituent, CUR, for treating of inflammatory, oxidative, and immune dysregulation disorders.

中文翻译：

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姜黄和姜黄素抗炎、抗氧化和免疫调节作用的实验和临床报告，更新和全面审查

Curcuma longa ( C. longa ) 或姜黄是一种在传统医学中使用历史悠久的植物，特别是用于治疗炎症性疾病C. longa及其主要成分姜黄素 (CUR) 显示出多种药理作用，如抗氧化和抗炎症。微生物特性。这篇综述文章提供了关于C. longa和 CUR的抗炎、抗氧化和免疫调节作用的最新知识。在 2020 年 9 月之前，使用各种数据库和适当的关键字搜索了C. longa和 CUR 的药理作用，包括抗炎、抗氧化和免疫调节特性。 各种研究显示了C. longa的抗炎作用和 CUR，包括降低白细胞、中性粒细胞和嗜酸性粒细胞数量，及其对不同炎症性疾病中炎症介质（如磷脂酶 A2 和总蛋白）的血清水平的保护作用。C. longa和 CUR的抗氧化作用也在几项研究中有所报道。在氧化应激条件下，植物提取物和 CUR 降低了丙二醛和一氧化氮的水平，但增加了硫醇、超氧化物歧化酶和过氧化氢酶的水平。C. longa和 CUR治疗还改善了免疫球蛋白 E (Ig)E、促炎细胞因子白细胞介素 4 (IL)-4、转化生长因子-β、IL-17、干扰素-γ 水平和 1 型/2 型辅助因子免疫系统紊乱情况下的细胞 (Th1)/(Th2) 比率。所以C. longa和 CUR 显示出抗炎、抗氧化和免疫调节作用，表明该植物及其成分 CUR 对治疗炎症、氧化和免疫失调疾病具有潜在的治疗作用。