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Study on peptide-peptide interactions between transmembrane domains of Slc11a1 in model membranes
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.4 ) Pub Date : 2021-02-19 , DOI: 10.1016/j.saa.2021.119594 Haiyan Qi , Xiuwen Wang , Liqiang Su , Shu Wang , Ying Wang
中文翻译:
模型膜中Slc11a1跨膜结构域之间的肽-肽相互作用研究
更新日期:2021-03-01
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.4 ) Pub Date : 2021-02-19 , DOI: 10.1016/j.saa.2021.119594 Haiyan Qi , Xiuwen Wang , Liqiang Su , Shu Wang , Ying Wang
In this study, we determined the interaction between TM4 and TM2/TM3 domain of Solute carrier family 11 member 1 (Slc11a1) by circular dichroism (CD) and fluorescence spectrum. The results indicated that, the cation transport process was likely to be accomplished by the collaboration of multiple TM domains rather than by TM4 domain alone. Therefore, this finding suggested possible transportation theory and be helpful to elucidate the mechanism of Slc11a1 in cation transport process.
中文翻译:
模型膜中Slc11a1跨膜结构域之间的肽-肽相互作用研究
在这项研究中,我们通过圆二色性(CD)和荧光光谱确定了溶质载体家族11成员1(Slc11a1)的TM4和TM2 / TM3域之间的相互作用。结果表明,阳离子转运过程很可能是通过多个TM域的协作来完成的,而不是仅通过TM4域的协作来完成的。因此,这一发现提出了可能的输运理论,并有助于阐明Slc11a1在阳离子输运过程中的机理。