4-hydroxy-l-proline (Hyp) is a ubiquitous amino acid naturally-occurred in proteins such as collagens. Owing to the easy accessibility and unique structural features, Hyp can be exploited as an interesting building block for the design of novel biomimetic and biodegradable polymers with fascinating materials properties and biological applications. This review highlights recent progresses regarding Hyp-derived polymers and oligomers including polypeptides, polyesters, polythioesters, γ-peptides, and oligourethanes, with an emphasis on the structural design and synthesis. Perspective and future directions are briefly summarized at the end of review.

中文翻译：

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羟脯氨酸衍生的仿生生物可降解聚合物

4-羟基-1-脯氨酸（Hyp）是蛋白质（例如胶原蛋白）中天然存在的普遍存在的氨基酸。由于易于访问和独特的结构特征，Hyp可以用作有趣的构建基，用于设计具有令人着迷的材料特性和生物学应用的新型仿生和可生物降解聚合物。这篇综述重点介绍了Hyp衍生的聚合物和低聚物，包括多肽，聚酯，聚硫酯，γ肽和低聚乙烷的最新进展，重点是结构设计和合成。回顾结束时简要概述了前景和未来方向。