当前位置: X-MOL 学术Adoption & Fostering › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Stress and physiology in clinical research with risk-exposed children: from mechanism to application
Adoption & Fostering Pub Date : 2019-09-26 , DOI: 10.1177/0308575919856162
Thomas G O’Connor 1 , Ana Vallejo Sefair 2
Affiliation  

Research findings from diverse studies converge in suggesting that the experience of early severe and protracted stress is associated with a wide range of behavioural and physical health problems. The public health and clinical implications of these findings are substantial, but their successful applications to improve child health have been limited. What is clear is that this successful application depends, at least in part, on a clear understanding of the mechanisms involved. The current review considers the likely role of stress physiology and the Hypothalamic-Pituitary-Adrenal (HPA) axis, one dominant model for explaining how early stress exposures may have lasting effects on mental and physical health. In addition to highlighting illustrative findings, we consider the practical barriers and challenges for increasing the presence of biological markers in clinical research.

中文翻译:

风险暴露儿童临床研究中的压力和生理学:从机制到应用

来自不同研究的研究结果一致表明,早期严重和长期压力的经历与广泛的行为和身体健康问题有关。这些发现对公共卫生和临床意义重大,但它们在改善儿童健康方面的成功应用受到限制。显而易见的是,这种成功的应用至少部分取决于对所涉及机制的清晰理解。当前的审查考虑了压力生理学和下丘脑-垂体-肾上腺 (HPA) 轴的可能作用,这是解释早期压力暴露如何对身心健康产生持久影响的一种主要模型。除了突出说明性发现之外,
更新日期:2019-09-26
down
wechat
bug