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A.E.Favorskii’s scientific legacy in modern organic chemistry: prototropic acetylene – allene isomerization and the acetylene zipper reaction
Russian Chemical Reviews ( IF 7.7 ) Pub Date : 2020-01-02 , DOI: 10.1070/rcr4902
Natalia A. Danilkina , Anna A. Vasileva , Irina A. Balova

Alexei Evgrafovich Favorskii was an outstanding organic chemist who left a great scientific legacy as a result of long time and fruitful work. Most of the theoretically and practically important discoveries of A.E.Favorskii were made in the chemistry of acetylene and its derivatives. Nowadays, the reactions discovered by him, which include acetylene – allene isomerization, the Favorskii and retro-Favorskii reactions, the Favorskii rearrangement and the vinylation reaction, are widely used in industry and in laboratory synthesis. This review summarizes the main scientific achievements of A.E.Favorskii, as well as their development in modern organic chemistry. Much consideration is given to acetylene – allene isomerization as a convenient method for the synthesis of methyl-substituted acetylenes and to the acetylene zipper reaction as a synthetic tool for obtaining terminal acetylenes. The review presents examples of the application of these reactions in modern organic synthesis of complex molecules, including natural compounds and their analogues.

The bibliography includes 266 references.



中文翻译:

AEFavorskii在现代有机化学中的科学遗产:原生质子乙炔-丙二烯异构化和乙炔拉链反应

Alexei Evgrafovich Favorskii是一位杰出的有机化学家,由于长期的努力和丰硕的成果,他留下了巨大的科学遗产。AEFavorskii的大多数理论上和实践上重要的发现都是在乙炔及其衍生物的化学中进行的。如今,他发现的反应包括乙炔-丙二烯异构化,Favorskii和逆Favorskii反应,Favorskii重排和乙烯基化反应,已广泛用于工业和实验室合成中。这篇综述总结了AEFavorskii的主要科学成就以及它们在现代有机化学中的发展。乙炔-丙二烯异构化是合成甲基取代的乙炔的便捷方法,乙炔的拉链反应是获得末端乙炔的合成工具,已经得到了很多考虑。综述提供了这些反应在复杂分子(包括天然化合物及其类似物)的现代有机合成中的应用实例。

参考书目包括266种参考文献。

更新日期:2020-01-02
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