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Implementing Zn2+ ion and pH-value control into artificial mussel glue proteins by abstracting a His-rich domain from preCollagen
Soft Matter ( IF 3.4 ) Pub Date : 2021-2-5 , DOI: 10.1039/d0sm02118k
Sandra Arias 1, 2, 3, 4, 5 , Shahrouz Amini 6, 7, 8, 9 , Jana M. Krüger 1, 2, 3, 4, 5 , Lukas D. Bangert 1, 2, 3, 4, 5 , Hans G. Börner 1, 2, 3, 4, 5
Affiliation  

A His-rich domain of preCollagen-D found in byssal threads is derivatized with Cys and Dopa flanks to allow for mussel-inspired polymerization. Artificial mussel glue proteins are accessed that combine cysteinyldopa for adhesion with sequences for pH or Zn2+ induced β-sheet formation. The artificial constructs show strong adsorption to Al2O3, the resulting coatings tolerate hypersaline conditions and cohesion is improved by activating the β-sheet formation, that enhances E-modulus up to 60%.

中文翻译:

通过从preCollagen中提取富含His的结构域,将Zn2 +离子和pH值控制用于人造贻贝胶蛋白

在鼻股线中发现的富含His的preCollagen-D域用Cys和Dopa侧翼衍生化,以进行贻贝启发式聚合。获得了人工贻贝胶蛋白,该蛋白结合了半胱氨酸多巴的粘附力和pH或Zn 2+诱导的β-折叠形成的序列。人工构建物对Al 2 O 3表现出强吸附性,所得涂层可耐受高盐条件,并且通过激活β-片层形成可改善内聚力,从而将E模量提高至60%。
更新日期:2021-02-18
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