To compare the difference in central corneal thickness (CCT) measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer (Sirius, CSO, Italy) and ultrasound pachymetry (USP). A systematic literature search was conducted for relevant studies published on PubMed, Medline, EMBASE, and the Cochrane Library and ClinicalTrials.gov from inception to August 1st, 2019. Primary outcome measures were CCT measurements between Sirius and USP. A random effects model was used to pool CCT measurements. A total of twelve studies involving 862 eyes were included in this meta-analysis. The meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different (P < 0.0001). The mean difference between Sirius and USP was −11.26 μm with a 95% confidence interval (CI) (−16.92 μm, −5.60 μm). The heterogeneity was I2 = 60% (P = 0.004). CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than USP. However, it may be argued that the mean difference of 11.26 μm is not a clinically significant difference.

中文翻译：

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Sirius Scheimpflug–Placido与超声测厚法对比中央角膜厚度：荟萃分析

为了比较旋转的Scheimpflug相机与Placido-disk角膜地形图仪（Sirius，CSO，意大利）和超声测厚仪（USP）之间的正常眼睛中央角膜厚度（CCT）测量值的差异。从开始到2019年8月1日，对在PubMed，Medline，EMBASE以及Cochrane图书馆和ClinicalTrials.gov上发表的相关研究进行了系统的文献检索。主要的结局指标是Sirius和USP之间的CCT测量。使用随机效应模型合并CCT测量值。这项荟萃分析共包括十二项涉及862只眼睛的研究。荟萃分析发现Sirius和USP之间的CCT测量值在统计学上有显着差异（P <0.0001）。Sirius和USP之间的平均差异为-11.26μm，置信区间（CI）为95％（−16.92μm，-5.60μm）。异质性为I2 = 60％（P = 0.004）。Sirius Scheimpflug-Placido地形图仪的CCT测量值在统计学上显着低于USP。但是，可能会认为11.26μm的平均差异不是临床上的显着差异。