The utilization of bioactive constituent of peels and seeds provide an effective, environment friendly and inexpensive therapy for different forms of human disease, and the production, improvement and documentation of novel nutraceuticals. This review systematically presents findings and further understanding of the reported benefits and therapeutic applications of peel and seed extracts on innovative cell culture and animal studies, as well as phased clinical human trial research. The extracts of seed and peels were reported to possess high quantities of bioactive substances with antioxidative, antidiabetic, hepatorenal protective, antithyroidal, anti-inflammatory, antibacterial, cardiovascular protective, neuro-protective effects, anticancer and wound healing activities. Therapeutic activities of the bioactive substances of peel and seed extracts include elevation of Superoxide dismutase (SOD), GSH-Px, t-GPx, Catalase and GST activities, with the suppression of MDA levels, hydroperoxide generation and lipid peroxidized products, the extracts also regulate inflammatory mediators and cytokines as they are reported to suppress the secretion of inflammatory cytokines, which include; IL-1β, PGE2, TGF-β and TNF-α and induces apoptosis and cell differentiation. This review revealed the therapeutic importance and best utilization of peels and seed extracts of fruits and vegetables.

中文翻译：

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植物废物作为促进公共卫生的保健食品

利用果皮和种子的生物活性成分可为各种形式的人类疾病提供有效，环保且廉价的疗法，并提供新型保健食品的生产，改良和证明。这篇综述系统地介绍了果皮和种子提取物在创新性细胞培养和动物研究以及分阶段临床人体试验研究中所报道的益处和治疗应用方面的发现和进一步理解。据报道，种子和果皮的提取物具有大量的生物活性物质，具有抗氧化，抗糖尿病，肝肾保护，抗甲状腺，抗炎，抗菌，心血管保护，神经保护作用，抗癌和伤口愈合的作用。果皮和种子提取物的生物活性物质的治疗活性包括提高超氧化物歧化酶（SOD），GSH-Px，t-GPx，过氧化氢酶和GST活性，同时抑制MDA含量，产生过氧化氢和脂质过氧化产物，提取物也调节炎症介质和细胞因子，因为据报道它们可以抑制炎症细胞因子的分泌，包括：IL-1β，PGE2，TGF-β和TNF-α诱导细胞凋亡和细胞分化。这篇评论揭示了水果和蔬菜的果皮和种子提取物的治疗重要性和最佳利用。提取物还调节炎症介质和细胞因子，因为据报道它们可抑制炎症细胞因子的分泌，包括：IL-1β，PGE2，TGF-β和TNF-α诱导细胞凋亡和细胞分化。这篇评论揭示了水果和蔬菜的果皮和种子提取物的治疗重要性和最佳利用。提取物还调节炎症介质和细胞因子，因为据报道它们可抑制炎症细胞因子的分泌，包括：IL-1β，PGE2，TGF-β和TNF-α诱导细胞凋亡和细胞分化。这篇评论揭示了水果和蔬菜的果皮和种子提取物的治疗重要性和最佳利用。