Background: Studies have shown that the overall copy number variant (CNV) load is associated with schizophrenia. Schizophrenia is a mental disorder that is frequently associated with suicidal behavior. Methods: We recruited 263 patients with schizophrenia from the Centre for Addiction and Mental Health. The Columbia Suicide Severity Rating Scale was used to assess the presence of lifetime suicide attempt. Genotyping was completed using the Illumina Omni 2.5 chip. We tested the association between deletion events on chromosome 22 with suicide attempt in our schizophrenia sample. Results: There was no significant difference between suicide attempters and non-attempters considering the presence/absence of deletion events on chromosome 22. Conclusion: Although our results did not show a significant association between deletions on chromosome 22 and suicide attempt in schizophrenia, CNV studies may reveal important, novel insights and open further investigation for the treatment of neuropsychiatric diseases.
Neuropsychobiology

中文翻译：

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精神分裂症的22号染色体缺失和自杀行为

背景：研究表明，总体拷贝数变异 (CNV) 负荷与精神分裂症有关。精神分裂症是一种经常与自杀行为相关的精神障碍。方法：我们从成瘾和心理健康中心招募了 263 名精神分裂症患者。哥伦比亚自杀严重程度评定量表用于评估终生自杀未遂的存在。使用 Illumina Omni 2.5 芯片完成基因分型。我们在精神分裂症样本中测试了 22 号染色体上的缺失事件与自杀企图之间的关联。结果：考虑到 22 号染色体上是否存在缺失事件，自杀未遂者和未尝试者之间没有显着差异。结论：尽管我们的研究结果并未显示 22 号染色体上的缺失与精神分裂症患者的自杀企图之间存在显着关联，但 CNV 研究可能会揭示重要的、新颖的见解，并为神经精神疾病的治疗开启进一步的研究。
神经心理生物学