International Journal of Psychophysiology ( IF 3 ) Pub Date : 2021-02-18 , DOI: 10.1016/j.ijpsycho.2021.02.011 James E Arruda 1 , Jessica Steele 1 , Madison C McInnis 1 , Vanessa R Rainey 1 , Aaron Wade 2
As the number of individuals diagnosed with amnestic mild cognitive impairment (aMCI) and Alzheimer's dementia (AD) increases, a need exists for early detection and treatment of the disorders. A recent review of the literature conducted by Arruda et al. (2020) revealed that the latency of the flash visual-evoked potential-P2 (FVEP-P2) may possess pathognomic information that may assist in the early detection and treatment of each disease. Unfortunately, while group differences in latency are robust, the ability to discriminate between individuals remains difficult due to the natural variability associated with the FVEP-P2 latency. In the current investigation, we examine the role of wavelength of light in the production of the FVEP-P2, with the goal of reducing the variability associated with the FVEP-P2 latency and improving the diagnostic accuracy of the FVEP-P2 evaluation.
Method
Twenty-four healthy individuals (11 males and 13 females), ages 18 to 36 years (M = 25.00, SD = 5.60), participated in this investigation. Each participant experienced five blocks of 100 strobe flashes (or trials) under two different light conditions (blue filtered light and polychromatic white light) with their eyes closed. The FVEP-P2 associated with each trial was identified and the latency and amplitude of each component was calculated.
Result
The results of several repeated measures analysis of variance revealed no statistically significant differences in intra- and inter-individual variability associated with the P2 latency or amplitude. However, there was a significant difference in the amplitude of the P2 produced by the two lights, with blue filtered light producing significantly lower amplitudes than the polychromatic white light.
Conclusion
The results of the present investigation suggest that while imperfect, the current practice of employing polychromatic white light in the production of the FVEP-P2 remains the gold standard and that additional methods of reducing the natural variability of the P2 need to be developed if the FVEP-P2 latency is to be used as a biomarker.
中文翻译:
波长对闪光视觉诱发电位变异性的影响 P2:轻度认知障碍和阿尔茨海默病的潜在生物标志物
随着被诊断患有遗忘性轻度认知障碍 (aMCI) 和阿尔茨海默氏症 (AD) 的人数增加,需要及早发现和治疗这些疾病。Arruda 等人最近对文献进行了回顾。(2020) 揭示,闪光视觉诱发电位-P2 (FVEP-P2) 的潜伏期可能具有有助于早期发现和治疗每种疾病的病理学信息。不幸的是,虽然延迟的群体差异很大,但由于与 FVEP-P2 延迟相关的自然可变性,区分个体的能力仍然很困难。在当前的调查中,我们检查了光波长在 FVEP-P2 产生中的作用,
方法
24 名健康人(11 名男性和 13 名女性),年龄 18 至 36 岁(M = 25.00,SD = 5.60),参与了这项调查。每位参与者在闭眼的情况下在两种不同的光照条件(过滤蓝光和多色白光)下经历了 5 组 100 次频闪(或试验)。确定了与每个试验相关的 FVEP-P2,并计算了每个组件的潜伏期和幅度。
结果
多次重复测量方差分析的结果显示,与 P2 潜伏期或幅度相关的个体内和个体间变异性没有统计学上的显着差异。然而,两种光产生的 P2 的振幅存在显着差异,过滤蓝光产生的振幅明显低于多色白光。
结论
本调查的结果表明,虽然不完美,但目前在 FVEP-P2 生产中使用多色白光的做法仍然是黄金标准,如果 FVEP -P2 潜伏期将用作生物标志物。