Up to now, many improvements have been made in providing more therapeutic strategies for cancer patients. The lack of susceptibility to common therapies like chemo- and radio-therapy is one of the reasons why we need more methods in the field of cancer therapy. DNA damage response (DDR) is a set of mechanisms which identifies DNA lesions and triggers the repair process for restoring DNA after causing an arrest in the cell cycle. The ability of DDR in maintaining the genome stability and integrity can be favorable to cancerous cells which are exposed to radiation therapy or are treated with chemotherapeutic agents. When DDR mechanisms are error-free in cancer cells, they can escape the expected cellular death and display resistance to treatment. In this regard, targeting different components of DDR can help to increase the susceptibility of advanced tumors to chemo- and radio-therapy.

到目前为止，在为癌症患者提供更多治疗策略方面已经取得了许多改进。对化疗和放疗等常见疗法缺乏敏感性是我们在癌症治疗领域需要更多方法的原因之一。DNA 损伤反应 (DDR) 是一组机制，可识别 DNA 损伤并在导致细胞周期停滞后触发修复过程以恢复 DNA。DDR 在维持基因组稳定性和完整性方面的能力可能有利于接受放射治疗或接受化疗药物治疗的癌细胞。当 DDR 机制在癌细胞中没有错误时，它们可以逃避预期的细胞死亡并表现出对治疗的抵抗力。在这方面，