Here we argue in support of the human leukocyte antigen (HLA) supergene as a tumor suppressor. HLA is a recurring mutational target in a large and diverse group of malignancies. The tumor suppressor function of HLA is linked to an embryonic/stemness and drug resistance phenotype. A deeper understanding of the distinct roles of HLA, including immunosurveillance, stemness, and tumor suppressor functions, could illuminate the limited responses in cancer patients. Furthermore, it would provide guidelines for the design of new therapeutic strategies, including the potential of modulating HLA expression in the tumor stem cell compartment.

中文翻译：

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人类白细胞抗原作为候选肿瘤抑制因子

在这里，我们主张支持人类白细胞抗原 ( HLA ) 超基因作为肿瘤抑制因子。HLA是一大群多样的恶性肿瘤中反复出现的突变靶点。HLA的肿瘤抑制功能与胚胎/干性和耐药性表型有关。更深入地了解HLA的独特作用，包括免疫监视、干性和肿瘤抑制功能，可以阐明癌症患者的有限反应。此外，它将为设计新的治疗策略提供指导，包括调节肿瘤干细胞区室中HLA表达的潜力。