In the approach of biomolecules to a nanopore, it is essential to capture the effects of hydrodynamic anisotropy of the molecules and the near-wall hydrodynamic interactions which hinder their diffusion. We present a detailed theoretical analysis of the behaviour of a rod-like molecule attracted electrostatically by a charged nanopore. We first estimate the time scales corresponding to Brownian and electrostatic translations and reorientation. We find that Brownian motion becomes negligible at distances within the pore capture radius, and numerically determine the trajectories of the nano-rod in this region to explore the effects of anisotropic mobility. This allows us to determine the range of directions from the pore in which hydrodynamic interactions with the boundary shape the approach dynamics and need to be accounted for in detailed modelling.

中文翻译：

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纳米孔捕获棒状分子的流体动力学效应

在生物分子接近纳米孔的过程中，必须捕捉分子的流体动力学各向异性和阻碍其扩散的近壁流体动力学相互作用的影响。我们对由带电纳米孔静电吸引的棒状分子的行为进行了详细的理论分析。我们首先估计对应于布朗和静电平移和重新定向的时间尺度。我们发现布朗运动在孔隙捕获半径内的距离可以忽略不计，并通过数值确定该区域中纳米棒的轨迹以探索各向异性流动性的影响。