The plant Stryphnodendron adstringens is a species of legume in the genus Stryphnodendron that is found in Brazil. It is also known as “barbatimão-verdadeiro” and it is popularly used in folk medicine due to its healing properties. Purpose: The aim of this study was to evaluate the healing activity of hydrogel, together with an S. adstringens hydroalcoholic extract, in diabetic and non-diabetic rats. Methods: The phytochemical analysis of the S. adstringens hydroalcoholic extract was evaluated through HPLC and its antioxidant activity was measured by the DPPH assay. The cytotoxicity, the scratch assay, and the fibroblast cell proliferation were also evaluated. Forty (40) Wistar rats were submitted to an excision for a full-thickness wound of 1.5 cm × 1.5 cm in their dorsum. The animals were treated twice a day over 16 days, with a rich layer of the corresponding treatment: Hydrogel; Hydrogel associated with 5% S. adstringens hydroalcoholic extract (H + SAHE); S. adstringens hydroalcoholic extract (SAHE); Collagenase with Chloramphenicol; or Carbopol. Morphological and histological analyses of the injury were performed. Results: The phytochemical analysis of SAHE indicated the presence of phenolic compounds, tannins, and flavonoids. The hydroalcoholic extract showed strong antioxidant activities (IC50 = 25.56 ± 1.04 μg/mL). H + SAHE induced the fibroblast proliferation (148 ± 6.9%) and it was not cytotoxic. The association with H + SAHE showed a more pronounced healing activity than did the other treatments in the non-diabetic animals and in the diabetic animals, hence, promoting angiogenesis and reepithelialization. Conclusion: Under these scenarios, this study has demonstrated effectiveness in the recovering wounds of diabetic rats.

中文翻译：

---

与水凝胶结合时，Stryphnodendron束缚剂对糖尿病大鼠伤口愈合的益处

Stryphnodendron adstringens植物是Stryphnodendron属的一种豆科植物，在巴西发现。它也被称为“barbatimão-verdadeiro”，由于其具有治疗作用，因此广泛用于民间医学。目的：本研究的目的是评估水凝胶以及链霉链球菌水醇提取物在糖尿病和非糖尿病大鼠中的愈合活性。方法：采用高效液相色谱法（HPLC）对链霉链球菌水醇提取物进行植物化学分析，并通过DPPH法测定其抗氧化活性。还评估了细胞毒性，划痕测定和成纤维细胞增殖。对四十（40）只Wistar大鼠进行了切除，使其背部全长1.5厘米×1.5厘米。在16天内每天对动物进行两次治疗，具有丰富层的相应处理：水凝胶；与5％链霉菌（S. adstringens）水醇提取物（H + SAHE）相关的水凝胶 S. adstringens水醇提取物（SAHE）；含氯霉素的胶原酶；或Carbopol。对损伤进行了形态学和组织学分析。结果：SAHE的植物化学分析表明存在酚类化合物，单宁和类黄酮。该水醇提取物显示出强大的抗氧化活性（IC50 = 25.56±1.04μg/ mL）。H + SAHE诱导成纤维细胞增殖（148±6.9％），无细胞毒性。在非糖尿病动物和糖尿病动物中，与H + SAHE的结合显示出比其他治疗更显着的愈合活性，因此促进了血管生成和再上皮形成。结论：在这些情况下，