Sinonasal inverted papilloma (IP) has a propensity for malignant transformation. Although the IP-associated squamous cell carcinoma (SCC) is rare, it has a poor prognosis. To the best of our knowledge, this is the first study to assess IMP3 immunohistochemical (IHC) expression in sinonasal tumors and to compare it to the Ki-67 IHC expression and to other established clinicopathological parameters. A retrospective study was conducted on three groups which consisted of 72 cases of sinonasal IP, 20 age-matched samples of normal respiratory epithelium, and 15 cases of sinonasal SCC associated with IP, which were obtained from the archives of the Pathology Lab of Ain Shams University Specialized and Ain Shams University Hospitals during the period from January 2012 to December 2019. An IHC study was performed to evaluate IMP3 and Ki-67 expression in the three groups, with correlation of IMP3 expression to established clinicopathological parameters of sinonasal SCC on top of IP. Both IMP3 and Ki-67 showed a sharp rise in expression in the sinonasal SCC group. In addition, there were statistically significant differences in expression values between the 3 groups (). Receiver Operating Characteristic (ROC) analysis revealed that IMP3 and Ki-67 could be used to discriminate sinonasal SCC from control and IP lesions, with sensitivity and specificity of 100% and 81.5% for IMP3, respectively, and 100% and 62.5% for Ki-67, respectively. Spearman’s rho revealed that both IMP3 and Ki-67 were significantly related to the lymph node and tumor stages but not to the tumor grade. ROC analysis was performed to select cut-off scores for progression and survival for IMP3, and accordingly, Kaplan-Meier analysis showed correlation between IMP3 and overall survival, local recurrence-free survival, and metastasis-free survival in sinonasal SCC cases at the selected cut-off values. Based on our results, IMP3 could serve as a promising diagnostic, prognostic, and therapeutic marker for IP-associated sinonasal SCC.

中文翻译：

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IMP3免疫组化在倒置乳头状瘤和倒置乳头状瘤相关鼻窦鳞状细胞癌中的表达

鼻腔内翻性乳头状瘤（IP）有恶变倾向。尽管 IP 相关鳞状细胞癌 (SCC) 很少见，但预后较差。据我们所知，这是第一项评估 IMP3 免疫组织化学 (IHC) 在鼻腔鼻腔肿瘤中的表达并将其与 Ki-67 IHC 表达和其他已建立的临床病理参数进行比较的研究。对三组进行回顾性研究，其中包括 72 例鼻窦 IP、20 例年龄匹配的正常呼吸道上皮样本和 15 例与 IP 相关的鼻窦 SCC，这些样本来自 Ain Shams 病理实验室的档案。 2012 年 1 月至 2019 年 12 月期间，大学专科医院和艾因夏姆斯大学医院。进行了一项 IHC 研究以评估三组中 IMP3 和 Ki-67 的表达，其中 IMP3 表达与 IP 上已建立的鼻窦 SCC 临床病理参数的相关性。IMP3 和 Ki-67 在鼻窦 SCC 组中的表达都显示出急剧上升。此外，3组间表达值差异有统计学意义（）。接受者操作特征 (ROC) 分析显示 IMP3 和 Ki-67 可用于区分鼻窦 SCC 与对照和 IP 病变，对 IMP3 的敏感性和特异性分别为 100% 和 81.5%，对 Ki 的敏感性和特异性分别为 100% 和 62.5% -67，分别。Spearman's rho 显示 IMP3 和 Ki-67 均与淋巴结和肿瘤分期显着相关，但与肿瘤分级无关。进行 ROC 分析以选择 IMP3 进展和生存的截止分数，因此，Kaplan-Meier 分析显示 IMP3 与所选鼻窦 SCC 病例的总生存期、局部无复发生存期和无转移生存期之间存在相关性。截止值。根据我们的研究结果，IMP3 可以作为 IP 相关鼻窦 SCC 的有希望的诊断、预后和治疗标志物。