To date, most data regarding the crosstalk between the Wnt signaling pathway and the YAP/TAZ transcriptional coactivators focuses on the Wnt/β-catenin branch of the pathway. In contrast, the relationship between the non-canonical Wnt pathway and YAP/TAZ remains significantly less explored. Wnt5a is usually regarded as a prototypical non-canonical Wnt ligand, and its expression has been related to cancer progression. On the other hand, YAP/TAZ transcriptional coactivators act in concert with TEAD transcription factors to control gene expression. Although one article has shown previously that WNT5A is a YAP/TEAD target gene, there is a need for further evidence supporting this regulatory relationship, because a possible YAP/Wnt5a regulatory circuit might have profound implications for cancer biology. This article analyzes publicly available ChIP-Seq, gene expression, and protein expression data to explore this relationship, and shows that WNT5A might be a YAP/TEAD target gene in several contexts. Moreover, Wnt5a and YAP expression are significantly correlated in specific cancer types, suggesting that the crosstalk between YAP/TAZ and the Wnt pathway is more intricate than previously thought.

中文翻译：

---

癌症中WNT5A与YAP / TEAD信号传导之间的功能相互作用的计算机分析

迄今为止，有关Wnt信号通路与YAP / TAZ转录共激活因子之间串扰的大多数数据都集中在该通路的Wnt /β-catenin分支上。相比之下，非经典Wnt途径和YAP / TAZ之间的关系仍然少有探索。Wnt5a通常被认为是原型的非规范Wnt配体，其表达与癌症进展有关。另一方面，YAP / TAZ转录共激活因子与TEAD转录因子协同作用以控制基因表达。尽管以前有一篇文章表明WNT5A是YAP / TEAD靶基因，但仍需要更多证据支持这种调节关系，因为可能的YAP / Wnt5a调节回路可能对癌症生物学产生深远影响。本文分析了公开可用的ChIP-Seq，基因表达和蛋白质表达数据来探讨这种关系，并表明WNT5A在某些情况下可能是YAP / TEAD靶基因。此外，Wnt5a和YAP表达在特定的癌症类型中显着相关，这表明YAP / TAZ与Wnt途径之间的串扰比以前认为的更为复杂。