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Highly sensitive and ratiometric luminescence sensing of heparin through templated cyanostilbene assemblies
Analyst ( IF 4.2 ) Pub Date : 2021-2-10 , DOI: 10.1039/d0an01808b
Shubhra Kanti Bhaumik 1, 2, 3, 4 , Supratim Banerjee 1, 2, 3, 4
Affiliation  

The assembly of organic dyes on bio-molecular templates is an attractive strategy for the creation of bio-materials with intriguing optical properties. This principle is exploited here for the detection of polyanion heparin, a known anticoagulant, by employing di-cationic cyanostilbene derivatives with inherent aggregation induced emission (AIE) features. The cyanostilbene derivatives exhibited weak cyan-blue monomeric emissions in solutions but upon electrostatic co-assembly with heparin, formed highly luminescent clusters on the polyanion surface. The cyanostilbene chromophores in the clusters exhibited greenish-yellow excimer emissions with remarkably longer life-times (up to 70-fold) and higher quantum yields (up to 85-fold) compared to their aqueous solutions. This led to heparin detection in aqueous buffer in low nanomolar concentrations. Additionally, and more importantly, a ratiometric detection of heparin was achieved in highly competitive media such as 50% human serum and 60% human plasma in medically relevant concentrations.

中文翻译:

肝素通过模板化的氰基二苯乙烯组装体的高灵敏度和比例发光检测

在生物分子模板上组装有机染料是一种吸引人的策略,可用于创建具有吸引人的光学特性的生物材料。通过使用具有固有聚集诱导发射(AIE)特征的双阳离子氰基二苯乙烯衍生物,此原理可用于检测聚阴离子肝素(一种已知的抗凝剂)。氰基茂金属衍生物在溶液中显示出较弱的蓝绿色单体发射,但与肝素进行静电共组装后,在聚阴离子表面上形成了高度发光的簇。与水溶液相比,簇中的氰基二茂铁发色团表现出绿黄色的准分子发射,具有更长的寿命(高达70倍)和更高的量子产率(高达85倍)。这导致在低纳摩尔浓度的水性缓冲液中检测肝素。
更新日期:2021-02-16
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