Micellar liquid chromatography was employed for the quantification and separation of the antidepressant drug clozapine (CLZ) and antiepileptic agent phenytoin (PHY). This mixture was separated using C8 column operating at 40°C using a mobile phase consisting of 0.075 M sodium dodecyl sulphate (SDS), 10% acetonitrile, 0.3% triethylamine (TEA), adjusted to pH 2.5 by 2 M ortho-phosphoric acid and applying a simple gradient program starting with a flow rate of 0.8 mL/min for the first 10 min of analysis applying 220 nm as detection wavelength, followed by raising the flow rate to 1.5 mL/min till end of analysis, adopting UV detection wavelength of 250 nm. The proposed method was used to quantify the concentration of both (CLZ) and (PHY) in rat whole blood whether spiked or in vivo suggesting its utility as a diagnostic tool for intoxication with either drugs in emergency rooms.

胶束液相色谱法用于抗抑郁药氯氮平（CLZ）和抗癫痫药苯妥英钠（PHY）的定量和分离。使用在80°C下操作的C8柱分离此混合物，使用的流动相为0.075 M十二烷基硫酸钠（SDS），10％乙腈，0.3％三乙胺（TEA），用2 M正磷酸将pH调节至2.5应用简单的梯度程序，以220 nm作为检测波长，在分析的前10分钟以0.8 mL / min的流速开始，然后将流速提高至1.5 mL / min直至分析结束，采用的UV检测波长为250纳米 所提出的方法用于定量大鼠全血中（CLZ）和（PHY）的浓度，无论是加标还是体内 建议将其用作诊断工具，用于急诊室中的任何一种药物中毒。