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The beneficial effects of a multistrain potential probiotic, formic, and lactic acids with different vaccination regimens on broiler chickens challenged with multidrug-resistant Escherichia coli and Salmonella
Saudi Journal of Biological Sciences ( IF 4.4 ) Pub Date : 2021-02-16 , DOI: 10.1016/j.sjbs.2021.02.017
Mohamed Sabry Abd Elraheam Elsayed , Awad A. Shehata , Ahmed Mohamed Ammar , Tamer S. Allam , Abdallah S. Ali , Rasha H. Ahmed , A.B. Abeer Mohammed , Reda Tarabees

The effects of a multistrain potential probiotic (Protexin®), acids, and a bacterin from multidrug-resistant E. coli O26, O78, S. Enteritidis (1,9,12 g.m1,7), and S. Typhimurium (1,4,5,12.i.1,2) on the immune response, haematological parameters, cytokines, and growth parameters of broiler chickens challenged with bacterin live serotypes were investigated. Two experiments were designed using 300 one-day-old chicks (Arbor Acres) randomly assigned to 15 groups. The first experiment comprised 9 groups, including positive and negative control groups and other groups received Protexin®, acids, and the bacterin (0.2 ml/SC), either alone or in combination, on the 1st day. The second experiment contained 6 groups, including positive and negative control groups and other groups received a combination of Protexin®, acids, and the bacterin (0.5 ml/SC) on the 8th day. All the groups except the negative control groups were challenged on the 8th and 16th days in both experiments, respectively, with mixed live bacterin serotypes. The groups that received Protexin®, acids, and the bacterin either alone or in combination revealed significant improvements in the immune response to the bacterin (p ≤ 0.05). The groups in the 1st experiment and most the 2nd experiment groups showed a reduced mortality rate and decreased levels IFN-γ, IL-4, and IL-12 cytokines (p ≤ 0.05). Moreover, these groups demonstrated increases in haematological parameters and reduced rates of infection-caused anaemia. These groups showed significant increases in growth performance parameters, such as body weight, weight gain, and the feed conversion ratio (FCR) (p ≤ 0.05). There was a beneficial effect on 1-day-old chickens produced by combining Protexin®, acids, and the bacterin (0.2 ml/SC).



中文翻译:

具有不同疫苗接种方案的多菌株潜在益生菌,甲酸和乳酸对受多重耐药性大肠杆菌沙门氏菌攻击的肉鸡的有益影响

一个潜在multistrain益生菌的(Protexin®)的影响,酸,和从耐药菌苗大肠杆菌O26,O78,S.肠炎(1,9,12 g.m1,7),和S.研究了鼠伤寒沙门氏菌(1,4,5,12.i.1,2)对活菌型激发的肉鸡的免疫应答,血液学参数,细胞因子和生长参数的影响。使用随机分为15组的300只1天大的雏鸡(乔木英亩)设计了两个实验。第一个实验包括9组,包括阳性和阴性对照组,其他组在第一天单独或联合接受Protexin®,酸和细菌素(0.2 ml / SC)。第二个实验包含6组,包括阳性和阴性对照组,其他组在第8天接受了Protexin®,酸和细菌素(0.5 ml / SC)的组合。在两个实验中,除阴性对照组外,其他所有组均分别在第8天和第16天进行攻击,混合活细菌血清型。单独或联合接受Protexin®,酸和细菌的组显示出对该细菌的免疫反应有显着改善(p≤0.05)。第一个实验组和大多数第二个实验组的死亡率降低,IFN-γ,IL-4和IL-12细胞因子水平降低(p≤0.05)。而且,这些组证明了血液学参数的增加和感染引起的贫血的发生率降低。这些组的生长性能参数(例如体重,增重和饲料转化率(FCR))显着增加(p≤0.05)。通过将Protexin®,酸和细菌素(0.2 ml / SC)混合,对1天大的鸡产生了有益的影响。并且单独或联合使用的细菌素均显示出对该细菌素的免疫反应有显着改善(p≤0.05)。第一个实验组和大多数第二个实验组的死亡率降低,IFN-γ,IL-4和IL-12细胞因子水平降低(p≤0.05)。而且,这些组证明了血液学参数的增加和感染引起的贫血的发生率降低。这些组的生长性能参数(例如体重,增重和饲料转化率(FCR))显着增加(p≤0.05)。通过将Protexin®,酸和细菌素(0.2 ml / SC)混合,对1天大的鸡产生了有益的影响。并且单独或联合使用的细菌素均显示出对该细菌素的免疫反应有显着改善(p≤0.05)。第一个实验组和大多数第二个实验组的死亡率降低,IFN-γ,IL-4和IL-12细胞因子水平降低(p≤0.05)。而且,这些组证明了血液学参数的增加和感染引起的贫血的发生率降低。这些组的生长性能参数(例如体重,增重和饲料转化率(FCR))显着增加(p≤0.05)。通过将Protexin®,酸和细菌素(0.2 ml / SC)混合,对1天大的鸡产生了有益的影响。第一个实验组和大多数第二个实验组的死亡率降低,IFN-γ,IL-4和IL-12细胞因子水平降低(p≤0.05)。而且,这些组证明了血液学参数的增加和感染引起的贫血的发生率降低。这些组的生长性能参数(例如体重,增重和饲料转化率(FCR))显着增加(p≤0.05)。通过将Protexin®,酸和细菌素(0.2 ml / SC)混合,对1天大的鸡产生了有益的影响。第一个实验组和大多数第二个实验组的死亡率降低,IFN-γ,IL-4和IL-12细胞因子水平降低(p≤0.05)。而且,这些组证明了血液学参数的增加和感染引起的贫血的发生率降低。这些组的生长性能参数(例如体重,增重和饲料转化率(FCR))显着增加(p≤0.05)。通过将Protexin®,酸和细菌素(0.2 ml / SC)混合,对1天大的鸡产生了有益的影响。这些组的生长性能参数(例如体重,增重和饲料转化率(FCR))显着增加(p≤0.05)。通过将Protexin®,酸和细菌素(0.2 ml / SC)混合,对1天大的鸡产生了有益的影响。这些组的生长性能参数(例如体重,增重和饲料转化率(FCR))显着增加(p≤0.05)。通过将Protexin®,酸和细菌素(0.2 ml / SC)混合,对1天大的鸡产生了有益的影响。

更新日期:2021-02-16
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