The enduring adoption of greener technologies from the biofuel manufacturing industries requires the balanced integration of multiple inter-disciplinary concerns (i.e., engineering, business, sustainability, societal) to make production processes more attractive to the industrial sector. From an engineering perspective, the commercial establishment of lignocellulosic bioethanol plants is still hindered by increased production cost. High product concentrations with improved yield and productivity at the fermentation stage seem to be inviolable condition to straightly compete with fossil-based and first-generation bioethanol facilities. This study proposes a model-based multi-objective dynamic optimization approach to systematically derive optimal operating policies for the fermentation bioreactor as a step forward towards enhancing the economic performance of lignocellulosic bioethanol plants. The economic benefit of the derived optimal bioreactor strategies is evaluated via a scalable economic index, linking for the first time the performance of the fermentation bioreactor to the economics of the entire production process. It is demonstrated that high values in productivity and substantial compromises in yield and final bioethanol concentration are conditions which favor economic feasibility with the achieved fermentation performance (3.32 g L⁻¹ h⁻¹, 0.399 g g⁻¹, 106.0 g L⁻¹) being comparable to first-generation bioethanol production. Finally, a global system analysis framework is employed to investigate the robustness of the optimal value of the economic index to the variability of key model parameters, illustrating the impact of model uncertainty on the process economic performance.

生物燃料制造行业不断采用更绿色的技术，需要多个学科间关注点（例如，工程，业务，可持续性，社会）的平衡整合，以使生产过程对工业部门更具吸引力。从工程角度看，木质纤维素生物乙醇工厂的商业化建设仍然受到生产成本增加的阻碍。在发酵阶段，高浓度的产品具有更高的产量和生产率，这似乎是与化石基和第一代生物乙醇工厂直接竞争的不可侵犯的条件。这项研究提出了一种基于模型的多目标动态优化方法，可以系统地得出发酵生物反应器的最佳操作策略，以此作为提高木质纤维素生物乙醇工厂经济性能的一步。通过可扩展的经济指标评估衍生的最佳生物反应器策略的经济效益，这是发酵生物反应器的性能首次与整个生产过程的经济性相关联。结果表明，较高的生产率值以及产量和最终生物乙醇浓度的重大折衷是有利于经济可行性和发酵性能的条件（3.32 g L 通过可扩展的经济指标评估衍生的最佳生物反应器策略的经济效益，这是发酵生物反应器的性能首次与整个生产过程的经济性挂钩。结果表明，较高的生产率值以及产量和最终生物乙醇终浓度的重大折衷是有利于经济可行性以及实现发酵性能的条件（3.32 g L 通过可扩展的经济指标评估衍生的最佳生物反应器策略的经济效益，这是发酵生物反应器的性能首次与整个生产过程的经济性挂钩。结果表明，较高的生产率值以及产量和最终生物乙醇浓度的重大折衷是有利于经济可行性和发酵性能的条件（3.32 g L^-1 ħ ^-1，0.399克克^-1，106.0克大号^-1）是相当于第一代生物乙醇生产。最后，采用一个全局系统分析框架来研究经济指标最佳值对关键模型参数的可变性的鲁棒性，从而说明模型不确定性对流程经济绩效的影响。