A nomogram from a British naturalistic study proposed that the clozapine dosing needed to reach a serum concentration of 350 ng/mL ranged from 265 mg/d (female nonsmokers) to 525 mg/d (male smokers). Some European reviews have used these dosing recommendations, which seem greater than what we found in an Italian White sample ranging from 245 mg/d (female nonsmokers) to 299 mg/d (male smokers). Five other published samples of European Whites were added to the Italian sample to estimate clozapine doses recommended for reaching 350 ng/mL.

中文翻译：

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欧洲白人可能需要比通常建议的最低治疗剂量更低的氯氮平。

来自英国自然主义研究的列线图表明，达到 350 ng/mL 血清浓度所需的氯氮平剂量范围为 265 mg/d（女性不吸烟者）至 525 mg/d（男性吸烟者）。一些欧洲评论使用了这些剂量建议，这似乎高于我们在意大利白人样本中发现的剂量，范围从 245 毫克/天（女性不吸烟者）到 299 毫克/天（男性吸烟者）。将另外五个已发表的欧洲白人样本添加到意大利样本中，以估计达到 350 ng/mL 的推荐氯氮平剂量。