Glycopolymers that can mimic natural glycosaminoglycan, such as heparin, have shown great potentials in inhibition of cancer metastasis. In the current work, a novel series of brush-like glycopolymers (BGPs) with simultaneous functionalization of various monosaccharide or disaccharide compositions have been synthesized through a new grafting-polymerization strategy, in order to mimic the activities of both heparin and P-selectin ligand PSGL-1. In the subsequent in vitro assays of antiadhesion, platelets activation, heparanase inhibition, and so on, BGP-SFH, as one of the BGPs with the composition of the combined three sugar units, sialic acids, fucoses, and heparin disaccharides, showed the highest antimetastasis ability, similar to its prototype heparin. Moreover, in a mouse metastatic melanoma model, the BGP-SFH also inhibited B16 cell metastasis effectively. Thus, the current work not only demonstrated a type of promising antimetastasis glycopolymer BGPs, but also illustrated an easy synthetic approach to multifunctionalized glycopolymers, leading to potential applications for broader biomedical research.

中文翻译：

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对P-选择蛋白具有高亲和力和抗肿瘤转移活性的多功能刷状糖聚合物

可以模拟天然糖胺聚糖的糖聚合物，例如肝素，在抑制癌症转移方面显示出巨大潜力。在当前的工作中，已经通过新的接枝聚合策略合成了一系列同时具有各种单糖或二糖成分功能的新型刷状糖聚合物（BGP），以模仿肝素和P-选择素配体的活性。 PSGL-1。在随后的抗粘附，血小板活化，乙酰肝素酶抑制等体外试验中，BGP-SFH作为由三个糖单元，唾液酸，岩藻糖和肝素二糖组合而成的BGP之一，表现出最高的抗转移能力，类似于其原型肝素。此外，在小鼠转移性黑色素瘤模型中，BGP-SFH也有效抑制了B16细胞的转移。因此，当前的工作不仅展示了一种有前途的抗转移糖聚合物BGP，而且还展示了一种简单的合成方法，用于多功能糖聚合物，从而为更广泛的生物医学研究提供了潜在的应用。