Abstract

Pyrazolone and its derivatives are an important class of heterocyclic compounds that are found in many drugs. They represent an interesting model for combinatorial and medicinal chemistry due to their simple preparation and their therapeutic and biological properties. Research on medicinal chemistry has drug-like pyrazolone candidates with various medicinal properties, including anti-inflammatory, antioxidant and antitumor activities, etc. Here, we summarize strategies to synthesize 3-amino-1-substituted-1H-pyrazol-5(4H)-ones and show that this class of compounds can be used as a kay intermediate for the discovery of new drugs and can be readily prepared owing to recent advances in synthetic medicinal chemistry.

摘要

吡唑啉酮及其衍生物是在许多药物中发现的一类重要的杂环化合物。由于它们的简单制备及其治疗和生物学特性，它们代表了一种有趣的组合化学和药物化学模型。药物化学研究具有类似药物的吡唑啉酮候选物，具有多种药物特性，包括抗炎，抗氧化和抗肿瘤活性等。在这里，我们总结了合成3-氨基-1-取代-1 H-吡唑-5（4）的策略。ħ） -酮和显示，这类化合物可被用作一个中间琦用于新药的发现，并且可以由于在合成药物化学的最新进展容易地制备。