Abstract

An expeditious approach for the synthesis of thiazolidin-2-imines and 1,3-thiazinan-2-imines through three-components coupling (TCC) of amines, isothiocynates and dihalides under metal-free conditions has been described. Dichloroethane (DCE) employed as two carbon (C2) source for the annulation and obtained saturated five membered heterocycles.With 1,3-dibromopropane, six membered heterocycles were obtained in good yields. The metal-free, broad substrate scope, functional group tolerance and applicability at gram scale synthesis are the advantages of the present protocol.

中文翻译：

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在无金属条件下通过胺，vic-二卤化物和异硫氰酸酯的三组分偶联合成噻唑烷亚胺/噻嗪南-2-亚胺

摘要

已经描述了一种在无金属条件下通过胺，异硫氰酸酯和二卤化物的三组分偶联（TCC）合成噻唑烷二-2-亚胺和1，3-噻嗪南-2-亚胺的快速方法。用二氯乙烷（DCE）作为两个碳（C2）源进行环化，得到饱和的五元杂环.1,3-二溴丙烷可得到六元杂环，收率很高。无金属，较宽的底物范围，官能团耐受性和克级合成的适用性是本方案的优点。