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Nbs1‐mediated DNA damage repair pathway regulates haematopoietic stem cell development and embryonic haematopoiesis
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-02-14 , DOI: 10.1111/cpr.12972
Yu Chen 1 , Jie Sun 2 , Zhenyu Ju 1 , Zhao‐Qi Wang 3, 4 , Tangliang Li 1, 5, 6
Affiliation  

DNA damages pose threats to haematopoietic stem cells (HSC) maintenance and haematopoietic system homeostasis. Quiescent HSCs in adult mouse bone marrow are resistant to DNA damage, while human umbilical cord blood‐derived proliferative HSCs are prone to cell death upon ionizing radiation. Murine embryonic HSCs proliferate in foetal livers and divide symmetrically to generate HSC pool. How murine embryonic HSCs respond to DNA damages is not well‐defined.

中文翻译:

Nbs1介导的DNA损伤修复途径调节造血干细胞发育和胚胎造血作用

DNA损伤对造血干细胞(HSC)的维持和造血系统的体内平衡构成威胁。成年小鼠骨髓中的静态HSC对DNA损伤具有抵抗力,而人脐带血来源的增殖性HSC在电离辐射下易于死亡。鼠胚胎HSCs在胎儿肝脏中增殖并对称分裂产生HSC库。尚不清楚鼠胚胎HSC如何对DNA损伤做出反应。
更新日期:2021-03-09
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