Superparamagnetic nanocarriers of poly (2‐hydroxyethyl methacrylate) (PHEMA) were prepared by carrying out benzoyl peroxide (BPO) initiated inverse emulsion‐free radical polymerization of HEMA in the presence of poly (vinyl alcohol) (PVA) and subsequent in situ precipitation of magnetite within the PHEMA matrix. The as‐prepared nanoparticles were characterized by FTIR and UV–visible spectroscopy, vibrating sample magnetometry (VSM), particle size and zeta potential analysis, and transmission electron microscopy, respectively. The PHEMA nanocarriers were investigated for their blood compatibility, and cytotoxicity response to L929 cells. The superparamagnetic nanoparticles were loaded with an anticancer drug cisplatin and the release profiles of the drug were examined as a function of various experimental parameters like composition of the PHEMA nanocarriers, percentage of drug loading, and strength of the externally imposed magnetic field. The kinetics of the drug release process was also investigated, and the obtained release data were applied to different mathematical kinetic models to explore the nature of the release mechanism.

中文翻译：

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逆乳液聚合辅助设计的超顺磁性聚（甲基丙烯酸2-羟乙酯）纳米颗粒和磁性触发的顺铂释放

聚（2-甲基丙烯酸羟乙酯）（PHEMA）的超顺磁性纳米载体是通过在聚乙烯醇（PVA）存在下进行过氧化苯甲酰（BPO）引发的HEMA乳液逆自由基聚合反应制备的。 PHEMA基质中的磁铁矿。制备的纳米颗粒分别通过FTIR和紫外可见光谱，振动样品磁力法（VSM），粒度和zeta电位分析以及透射电子显微镜进行表征。研究了PHEMA纳米载体的血液相容性以及对L929细胞的细胞毒性反应。将超顺磁性纳米颗粒负载抗癌药顺铂，并根据各种实验参数（例如PHEMA纳米载体的组成，药物负载百分比和外部施加的磁场强度）来检查该药物的释放曲线。还研究了药物释放过程的动力学，并将获得的释放数据应用于不同的数学动力学模型，以探索释放机理的性质。