Natural leather with outstanding biomimetic properties is the main application of animal skin. However, the traditional tannery industry is facing serious issues of sustainability, such as low value addition and high environmental pollution. Upscaled functional leather (UFL) inherits all the natural properties of leather and combines it with other cross-domain functions, due to which it has gained considerable attention as advanced functional bio-based materials. This review briefly introduces the multi-hierarchical structure and preponderant properties of leather as a natural biomass. Further emphasis is on UFL, which includes electromagnetic (EM) wave absorbing leather, infrared absorbing leather, X-ray shielding leather, flexible conductive leather, flame-retardant leather, antibacterial leather, self-cleaning leather as well as water-, oil-, and soil-repellent leather. Furthermore, the fabrication methods of these UFLs, their merits and their respective applications are comprehensively discussed. Moreover, possible challenges and outlooks for the development of UFL are proposed. This review describes how UFL will expand the scope of applications and significantly improve the ontological value of natural leather. Significantly, UFL is expected to boost the sustainable development of conventional leather industry and the next-generation of advanced functional bio-based materials.

具有出色仿生性能的天然皮革是动物皮肤的主要应用。但是，传统制革业面临着严重的可持续性问题，例如低附加值和高环境污染。高档功能皮革（UFL）继承了皮革的所有自然特性，并将其与其他跨领域功能结合在一起，因此，它作为先进的功能性生物基材料备受关注。本文简要介绍了皮革作为天然生物质的多层次结构和优越的性能。UFL进一步受到重视，它包括电磁波（EM）吸收皮革，红外吸收皮革，X射线屏蔽皮革，柔性导电皮革，阻燃皮革，抗菌皮革，自清洁皮革以及水，油，和防污皮革。此外，全面讨论了这些UFL的制造方法，优点和各自的应用。此外，提出了UFL发展的可能挑战和前景。这篇评论描述了UFL将如何扩展应用范围并显着提高天然皮革的本体价值。重要的是，UFL有望促进常规皮革行业和下一代高级功能性生物基材料的可持续发展。这篇评论描述了UFL将如何扩展应用范围并显着提高天然皮革的本体价值。重要的是，UFL有望促进常规皮革行业和下一代高级功能性生物基材料的可持续发展。这篇评论描述了UFL将如何扩展应用范围并显着提高天然皮革的本体价值。重要的是，UFL有望促进常规皮革行业和下一代高级功能性生物基材料的可持续发展。