To repair bone defects, a variety of bone substitution materials have been used, such as ceramics, metals, natural and synthetic polymers, and combinations thereof. In recent decades, a wide range of synthetic polymers have been used for bone regeneration. These polymers have the advantages of biocompatibility, biodegradability, good mechanical properties, low toxicity, and ease of processing. However, when used alone, they are unable to achieve ideal bone formation. Incorporating zinc (Zn) into synthetic polymers has been considered, as previous studies have shown that Zn2+ promotes stem cell osteogenesis and mineral deposition. The purpose of this systematic review was to provide an overview of the application and effectiveness of Zn in synthetic polymers for bone regeneration, whether used alone or in combination with other biomaterials. This study was performed according to the PRISMA guidelines. A search of the PubMed, Embase, and the Cochrane Library databases for articles published up to June 2020 revealed 153 relevant studies. After screening the titles, abstracts, and full texts, 13 articles were included in the review; 9 of these were in vitro, 3 were in vivo, and 1 included both in vitro and in vivo experiments. At low concentrations, Zn2+ promoted cell proliferation and osteogenic differentiation, while high-dose Zn2+ resulted in cytotoxicity and inhibition of osteogenic differentiation. Additionally, one study showed that Zn2+ reduced apatite formation in simulated body fluid. In all of the in vivo experiments, Zn-containing materials enhanced bone formation. At appropriate concentrations, Zn-doped synthetic polymer materials are better able to promote bone regeneration than materials without Zn.

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锌掺杂合成聚合物材料对骨骼再生的影响：系统评价

为了修复骨缺损，已使用多种骨替代材料，例如陶瓷，金属，天然和合成聚合物及其组合。近几十年来，各种各样的合成聚合物已用于骨骼再生。这些聚合物具有生物相容性，生物可降解性，良好的机械性能，低毒性和易于加工的优点。但是，当单独使用时，它们无法实现理想的骨形成。由于先前的研究表明Zn2 +促进干细胞成骨和矿物质沉积，因此已经考虑将锌（Zn）掺入合成聚合物中。本系统综述的目的是概述锌在合成聚合物中的应用及其有效性，这些合成聚合物可以单独使用，也可以与其他生物材料结合使用。这项研究是根据PRISMA指南进行的。在PubMed，Embase和Cochrane图书馆的数据库中，搜索到2020年6月为止发表的文章，发现153项相关研究。在筛选标题，摘要和全文之后，该评论包括了13篇文章；其中9个在体外，3个在体内，1个包括体外和体内实验。在低浓度下，Zn2 +促进细​​胞增殖和成骨分化，而高剂量Zn2 +则导致细胞毒性和抑制成骨分化。此外，一项研究表明，Zn2 +减少了模拟体液中磷灰石的形成。在所有的体内实验中，含锌材料增强了骨骼的形成。在适当的浓度下