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Impact of Different Exercise Modalities on the Human Gut Microbiome
Sports Pub Date : 2021-01-21 , DOI: 10.3390/sports9020014
Dierdra Bycura , Anthony C. Santos , Arron Shiffer , Shari Kyman , Kyle Winfree , Jay Sutliffe , Talima Pearson , Derek Sonderegger , Emily Cope , J. Gregory Caporaso

In this study we examined changes to the human gut microbiome resulting from an eight-week intervention of either cardiorespiratory exercise (CRE) or resistance training exercise (RTE). Twenty-eight subjects (21 F; aged 18–26) were recruited for our CRE study and 28 subjects (17 F; aged 18–33) were recruited for our RTE study. Fecal samples for gut microbiome profiling were collected twice weekly during the pre-intervention phase (three weeks), intervention phase (eight weeks), and post-intervention phase (three weeks). Pre/post VO2max, three repetition maximum (3RM), and body composition measurements were conducted. Heart rate ranges for CRE were determined by subjects’ initial VO2max test. RTE weight ranges were established by subjects’ initial 3RM testing for squat, bench press, and bent-over row. Gut microbiota were profiled using 16S rRNA gene sequencing. Microbiome sequence data were analyzed with QIIME 2. CRE resulted in initial changes to the gut microbiome which were not sustained through or after the intervention period, while RTE resulted in no detectable changes to the gut microbiota. For both CRE and RTE, we observe some evidence that the baseline microbiome composition may be predictive of exercise gains. This work suggests that the human gut microbiome can change in response to a new exercise program, but the type of exercise likely impacts whether a change occurs. The changes observed in our CRE intervention resemble a disturbance to the microbiome, where an initial shift is observed followed by a return to the baseline state. More work is needed to understand how sustained changes to the microbiome occur, resulting in differences that have been reported in cross sectional studies of athletes and non-athletes.

中文翻译:

不同运动方式对人肠道微生物组的影响

在这项研究中,我们研究了由心肺锻炼(CRE)或抵抗训练(RTE)进行的八周干预导致的人体肠道微生物组的变化。我们的CRE研究招募了28名受试者(21岁; 18-26岁),我们的RTE研究招募了28名受试者(17 F; 18-33岁)。在干预前阶段(三周),干预阶段(八周)和干预后阶段(三周),每周两次收集用于肠道微生物组分析的粪便样品。进行前/后VO 2max,三个重复最大值(3RM)和身体成分测量。CRE的心率范围取决于受试者的初始VO 2max测试。RTE体重范围是通过受试者对下蹲,卧推和弯腰的最初3RM测试确定的。使用16S rRNA基因测序分析肠道菌群。用QIIME 2分析微生物组序列数据。CRE导致肠道微生物组发生最初的变化,该变化在整个干预期间或之后都没有持续,而RTE导致肠道微生物组没有可检测到的变化。对于CRE和RTE,我们观察到一些证据表明基线微生物组组成可以预测运动量。这项工作表明,人类肠道微生物组可以响应新的锻炼计划而改变,但是锻炼的类型可能会影响是否发生改变。在我们的CRE干预中观察到的变化类似于对微生物组的干扰,观察到最初的变化,然后返回到基线状态。需要更多的工作来了解微生物组的持续变化是如何发生的,从而导致运动员和非运动员的横断面研究中报告的差异。
更新日期:2021-02-12
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