T helper 22 (Th22) cell populations are a newly identified subset of CD4⁺ T cells that primarily mediate biological effects on the epithelial barrier through interleukin (IL)‐22. Although, new studies showed that both Th22 and IL‐22 are closely associated with the pathogenesis of inflammatory, autoimmune and allergic disease as well as malignancies. In this review, we aim to describe the development and characteristics of Th22 cells as well as their roles in the immunopathogenesis of immune‐related disorders and cancer.

中文翻译：

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T辅助22细胞在免疫性疾病和恶性肿瘤中的特征和作用

T辅助22（Th22）细胞群是CD4 ⁺  T细胞的新近鉴定出的子集，主要通过白介素（IL）-22介导对上皮屏障的生物学作用。虽然，新的研究表明Th22和IL-22与炎症，自身免疫和过敏性疾病以及恶性肿瘤的发病机理密切相关。在这篇综述中，我们旨在描述Th22细胞的发育和特征，以及它们在免疫相关疾病和癌症的免疫发病机制中的作用。