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miR-106b as an emerging therapeutic target in cancer
Genes & Diseases ( IF 6.8 ) Pub Date : 2021-02-12 , DOI: 10.1016/j.gendis.2021.02.002
Surendra Kumar Sagar 1
Affiliation  

MicroRNAs (miRNAs) comprise short non-coding RNAs that function in regulating the expression of tumor suppressors or oncogenes and modulate oncogenic signaling pathways in cancer. miRNAs expression alters significantly in several tumor tissues and cancer cell lines. For example, miR-106b functions as an oncogene and increases in multiple cancers. The miR-106b directly targets genes involved in tumorigenesis, proliferation, invasion, migration, and metastases. This review has focused on the miR-106b function and its downstream target in different cancers and provide perspective into how miR-106 regulates cancer cell proliferation, migration, invasion, and metastases by regulating the tumor suppressor genes. Since miRNAs-based therapies are currently being developed to enhance cancer therapy outcomes, miR-106b could be an attractive and prospective candidate in different cancer types for detection, diagnosis, and prognosis assessment in the tumor.



中文翻译:

miR-106b 作为新兴的癌症治疗靶点

MicroRNAs (miRNAs) 包含短的非编码 RNA,其功能是调节肿瘤抑制因子或致癌基因的表达,并调节癌症中的致癌信号通路。miRNAs 表达在几种肿瘤组织和癌细胞系中发生显着变化。例如,miR-106b 作为致癌基因发挥作用,并在多种癌症中增加。miR-106b 直接靶向参与肿瘤发生、增殖、侵袭、迁移和转移的基因。本综述重点关注 miR-106b 在不同癌症中的功能及其下游靶点,并提供关于 miR-106 如何通过调节肿瘤抑制基因来调节癌细胞增殖、迁移、侵袭和转移的观点。由于目前正在开发基于 miRNA 的疗法以增强癌症治疗效果,

更新日期:2021-02-12
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