Over the last years, there has been an increasing trend towards the use of environmentally friendly processes to synthesize nanomaterials. In the case of nanomedicine, the use of bionanofactories with associated biological properties, such as seaweed, has emerged as a promising field of work due to the possibility they open for both the preservation of those properties in the nanomaterials synthesized and/or the reduction of their toxicity. In the present study, gold (Au@SP) and silver (Ag@SP) nanoparticles were synthesized using an aqueous extract of Saccorhiza polyschides (SP). Several techniques showed that the nanoparticles formed were spherical and stable, with mean diameters of 14 ± 2 nm for Au@SP and 15 ± 3 nm for Ag@SP. The composition of the biomolecules in the extract and the nanoparticles were also analyzed. The analyses performed indicate that the extract acts as a protective medium, with the particles embedded in it preventing aggregation and coalescence. Au@SP and Ag@SP showed superior immunostimulant and antiproliferative activity on immune and tumor cells, respectively, to that of the SP extract. Moreover, the nanoparticles were able to modulate the release of reactive oxygen species depending on the concentration. Hence, both nanoparticles have a significant therapeutic potential for the treatment of cancer or in immunostimulant therapy.

在过去的几年中，使用环境友好的方法来合成纳米材料的趋势越来越大。就纳米药物而言，具有相关生物学特性的生物纳米工厂（如海藻）的使用已成为一个有前途的工作领域，因为它们有可能在合成的纳米材料中保留这些特性和/或减少合成的纳米材料。它们的毒性。在本研究中，金黄色葡萄球菌（Au @ SP）和银（Ag @ SP）纳米粒子是使用沙棘多糖的水提取物合成的（SP）。几种技术表明，形成的纳米颗粒是球形且稳定的，Au @ SP的平均直径为14±2 nm，Ag @ SP的平均直径为15±3 nm。还分析了提取物和纳米颗粒中生物分子的组成。进行的分析表明，提取物可起到保护介质的作用，其中嵌入的颗粒可防止聚集和聚结。与SP提取物相比，Au @ SP和Ag @ SP分别对免疫细胞和肿瘤细胞表现出优异的免疫刺激和抗增殖活性。此外，纳米粒子能够根据浓度调节活性氧的释放。因此，两种纳米颗粒均具有用于癌症治疗或免疫刺激治疗的显着治疗潜力。