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Rapid hemostasis accompanied by antibacterial action of calcium crosslinking tannic acid-coated mesoporous silica/silver Janus nanoparticles
Biomaterials Advances ( IF 7.9 ) Pub Date : 2021-02-12 , DOI: 10.1016/j.msec.2021.111958
Jiawen Chen , Liping Qiu , Qinglin Li , Jie Ai , Haiqing Liu , Qinhui Chen

It is important to control bleeding and prevent bacterial infection for the wound people. The effective way is to fabricate an asymmetric Janus matrial for realizing rapid hemostasis and promoting wound healing. Herein, mesoporous silica nanoparticles (MSN) modified by tannic acid (TA), silver nanoparticles, and calcium ions (Ca-TA-MSN@Ag) with Janus structure were prepared via redox and coordination reactions. These anisotropic snowman-like particles possess obvious chemical compartition, in which silver nanoparticles are embedding in large MSN body. During blood coagulation, TA with catechol structure acts as a vasoconstrictor. Then, Ca-TA-MSN@Ag with high specific surface area (510.62 m2·g−1) and large pore volume (0.48 m3·g−1) induces red blood cell aggregation to form three-dimensional network structure with fibrin. Additionally, calcium ions as clotting factor IV and negative charge of Ca-TA-MSN@Ag accelerate coagulation cascade reaction. These three synergistic effects on animal model showed that hemostatic time of Ca-TA-MSN@Ag was shortened by nearly 50% compared to that of MSN. Moreover, Ca-TA-MSN@Ag possessed good blood compatibility, biocompatibility and antibacterial activity (~99%) against E. coli and S. aureus. The anisotropic Janus particles of Ca-TA-MSN@Ag with hemostatic performance and antibacterial activity will be a promising biomaterial for designing wound dressings in clinical application.



中文翻译:

快速止血并伴有钙交联鞣酸涂层介孔二氧化硅/银Janus纳米颗粒的抗菌作用

对于伤口人来说,控制出血和预防细菌感染很重要。有效的方法是制造不对称的Janus母材,以实现快速止血和促进伤口愈合。本文通过氧化还原和配位反应制备了单宁酸(TA),银纳米颗粒和钙离子(Ca-TA-MSN @ Ag)修饰的介孔二氧化硅纳米颗粒(MSN)。这些各向异性的雪人状颗粒具有明显的化学分布,其中银纳米颗粒嵌入大的MSN体内。在凝血过程中,具有儿茶酚结构的TA充当血管收缩剂。然后,Ca-TA-MSN @ Ag具有高比表面积(510.62 m 2 ·g -1)和大孔容(0.48 m 3 ·g-1)诱导红细胞聚集以与纤维蛋白形成三维网络结构。此外,钙离子作为凝血因子IV和Ca-TA-MSN @ Ag的负电荷会加速凝血级联反应。这三种对动物模型的协同作用表明,与MSN相比,Ca-TA-MSN @ Ag的止血时间缩短了近50%。此外,Ca-TA-MSN @ Ag对大肠杆菌金黄色葡萄球菌具有良好的血液相容性,生物相容性和抗菌活性(〜99%)。具有止血性能和抗菌活性的Ca-TA-MSN @ Ag各向异性的Janus颗粒将成为临床设计伤口敷料的有前途的生物材料。

更新日期:2021-02-19
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