Skin, being the protective barrier against the environment, can be subject to frequent trauma and stress, hence has the ability to heal itself rapidly. This capacity is attributed to a large number of resident stem cells and progenitors in the skin, which are activated to proliferate, migrate and differentiate to recreate the cellular diversity and regain tissue integrity. The barrier function of the skin is maintained by the epidermis, a multilayered epithelial compartment formed of keratinocytes. Wound repair evokes the capacity of cells to sense and respond to environmental cues. Tissue damage demands rapid cellular action, wherein spatio-temporally regulated cellular responses are critical determinants of the outcome of healing. Hence cells surrounding the wound have to immediately sense the damage and must activate the key signaling pathways to launch the wound-healing response. Emerging data is indicating that mechanical tension release is one of the first cues sensed by the neighboring cells of the damage. This cue is relayed by the cytoskeleton and converted into biochemical and cellular signals, which help the cells to respond accordingly to the trauma. In this review, we will focus on the role of keratinocytes and keratinocyte stem cells in wound healing, and the cytoskeletal dynamics involved therein.

皮肤是对环境的保护性屏障，会遭受频繁的创伤和压力，因此具有迅速自我修复的能力。这种能力归因于皮肤中大量驻留的干细胞和祖细胞，它们被激活以增殖，迁移和分化以重建细胞多样性并恢复组织完整性。皮肤的屏障功能由表皮维持，表皮是由角质形成细胞形成的多层上皮区室。伤口修复唤起了细胞感知和响应环境线索的能力。组织损伤需要快速的细胞作用，其中时空调节的细胞反应是治愈结果的关键决定因素。因此，伤口周围的细胞必须立即感觉到损伤，并且必须激活关键的信号传导途径以启动伤口愈合反应。新兴数据表明，机械张力释放是由邻近细胞感知到的损伤的第一个线索。该提示通过细胞骨架传递，并转换成生化和细胞信号，从而帮助细胞对创伤做出相应反应。在这篇综述中，我们将专注于角质形成细胞和角质形成干细胞在伤口愈合中的作用，以及其中涉及的细胞骨架动力学。帮助细胞对创伤做出相应的反应。在这篇综述中，我们将专注于角质形成细胞和角质形成干细胞在伤口愈合中的作用，以及其中涉及的细胞骨架动力学。帮助细胞对创伤做出相应的反应。在这篇综述中，我们将专注于角质形成细胞和角质形成干细胞在伤口愈合中的作用，以及其中涉及的细胞骨架动力学。